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Titolo:
P53 ALTERATION, PROLIFERATING CELL NUCLEAR ANTIGEN, AND NUCLEOLAR ORGANIZER REGIONS IN THYMIC EPITHELIAL TUMORS
Autore:
OYAMA T; OSAKI T; MITSUDOMI T; OGAWA R; NAKANISHI R; SUGIO K; YASUMOTO K;
Indirizzi:
VCC,649 MED RES BLDG 2,CARBONE LAB 648 NASHVILLE TN 37232 UNIV OCCUPAT & ENVIRONM HLTH,DEPT SURG 2 KITAKYUSHU FUKUOKA 807 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,DEPT INTERNAL MED 1 KITAKYUSHU FUKUOKA 807 JAPAN AICHI CANC CTR,DEPT THORAC SURG NAGOYA AICHI 464 JAPAN KYUSHU UNIV,SCH MED,DEPT SURG 2 FUKUOKA 810 JAPAN
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 5, volume: 1, anno: 1998,
pagine: 823 - 826
SICI:
1107-3756(1998)1:5<823:PAPCNA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA POLYMERASE-DELTA; LUNG-CANCER; PARAFFIN SECTIONS; PROGNOSTIC-SIGNIFICANCE; SHORTENED SURVIVAL; EXPRESSION; THYMOMAS; CHROMOSOMES; PATHOLOGY; CARCINOMA;
Keywords:
P53 GENE MUTATION; P53 EXPRESSION; PROLIFERATING CELL NUCLEAR ANTIGEN; ARGYROPHILIC NUCLEAR ORGANIZER REGIONS; THYMOMA; THYMIC CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
T. Oyama et al., "P53 ALTERATION, PROLIFERATING CELL NUCLEAR ANTIGEN, AND NUCLEOLAR ORGANIZER REGIONS IN THYMIC EPITHELIAL TUMORS", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1(5), 1998, pp. 823-826

Abstract

We examined p53 protein expression, p53 gene mutation, proliferating cell nuclear antigen (PCNA), and argyrophilic nuclear organizer regions (AgNOR), in 30 patients with surgically-treated thymic tumors (26 thymoma and 4 thymic carcinoma cases), p53 expression ratio with DO-1 was divided as p53 negative (0% positivity), low expressor (<10% positivity), high expressor (>10% positivity). The incidence of p53 low and high expressor in thymoma were 19% (5/26) and 8% (2/26), respectively. p53 immunopositivity in thymoma was significantly correlated with PCNAlabeling index (LI). p53 expression ratio in invasive thymoma (33%) tended to be higher than that in non-invasive thymoma (18%). p53 expression was detected in one of the thymic carcinoma. There were no p53 gene mutations in 15 invasive thymoma, although one of four (25%) thymiccarcinomas showed two point mutations, p53 gene alterations seem to be associated with malignant activity of tumor cells, and therefore detection of p53 gene mutations is useful as a diagnostic factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 03:28:39