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Titolo:
MOLECULAR DISSECTION OF B-CELL ANTIGEN RECEPTOR SIGNALING (REVIEW)
Autore:
KUROSAKI T;
Indirizzi:
KANSAI MED UNIV,INST LIVER RES,DEPT MOL GENET,10-15 FUMIZONO CHO MORIGUCHI OSAKA 570 JAPAN
Titolo Testata:
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
fascicolo: 3, volume: 1, anno: 1998,
pagine: 515 - 527
SICI:
1107-3756(1998)1:3<515:MDOBAR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; LYN-DEFICIENT MICE; X-LINKED AGAMMAGLOBULINEMIA; GLYCOGEN-SYNTHASE KINASE-3; VAV PROTOONCOGENE PRODUCT; INOSITOL PHOSPHATASE SHIP; PHOSPHORYLATED IG-ALPHA; FC-GAMMA-RIIB; PHOSPHATIDYLINOSITOL 3-KINASE; NEGATIVE REGULATION;
Keywords:
B CELL ANTIGEN; RECEPTOR SIGNALING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
115
Recensione:
Indirizzi per estratti:
Citazione:
T. Kurosaki, "MOLECULAR DISSECTION OF B-CELL ANTIGEN RECEPTOR SIGNALING (REVIEW)", INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1(3), 1998, pp. 515-527

Abstract

In B lymphocytes, signaling through the B cell antigen receptor (BCR)contributes to cell fate decisions with different extents of receptorengagement leading to such outcomes as cell death, survival, or proliferation. During the past several years we have seen significant strides in our understanding of the signaling pathways that connect the BCRto the nucleus. Stimulation of the BCR leads to the activation of three types of intracellular protein tyrosine kinases Lyn, Syk, and Btk. Concerted action of these tyrosine kinases leads to the phosphorylation of multiple substrates and to activation of a variety of signaling pathways including phospholipase C-gamma, Ras, and phosphatidylinositol3-kinase activation. The ability of B lymphocytes to react appropriately to a wide variety of environment stimuli requires a high degree ofregulation on these multiple signaling pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 22:50:24