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Titolo:
DIAGNOSIS OF OSTEOPOROSIS BY PLANAR BONE DENSITOMETRY - CAN BODY-SIZEBE DISREGARDED
Autore:
NIELSEN SP; KOLTHOFF N; BARENHOLDT O; KRISTENSEN B; ABRAHAMSEN B; HERMANN AP; BROT C;
Indirizzi:
CENT HOSP HILLEROD,DEPT CLIN PHYSIOL DK-3400 HILLEROD DENMARK ODENSE UNIV HOSP,DEPT MED M DK-5000 ODENSE C DENMARK AARHUS UNIV,AARHUS AMTSSYGEHUS,DEPT MED DK-8000 AARHUS C DENMARK KOMMUNE HOSP COPENHAGEN,OSTEOPOROSIS CTR DK-1399 COPENHAGEN K DENMARK
Titolo Testata:
British journal of radiology
fascicolo: 849, volume: 71, anno: 1998,
pagine: 934 - 943
Fonte:
ISI
Lingua:
ENG
Soggetto:
DXA PENCIL-BEAM; HIP FRACTURE; FAN-BEAM; SPINE DENSITOMETRY; MINERAL DENSITY; LUMBAR SPINE; RISK-FACTORS; WOMEN; ABSORPTIOMETRY; MASS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
S.P. Nielsen et al., "DIAGNOSIS OF OSTEOPOROSIS BY PLANAR BONE DENSITOMETRY - CAN BODY-SIZEBE DISREGARDED", British journal of radiology, 71(849), 1998, pp. 934-943

Abstract

Bone densitometry using dual energy X-ray absorptiometry (DXA) is frequently used to diagnose osteoporosis and to identify patients at riskof later fractures. The parameters of interest are bone mineral content (BMC) and bone mineral areal density (BMD). Bone densitometry results have a large overlap between normals and patients with fractures. This would suggest that other factors are important for the developmentof fractures or that bone densitometry is not used optimally. It is generally believed that the conversion of BMC to BMD by division of theformer by the projected bone area is a good normalization procedure. Other normalization procedures have been attempted in the past with little success. We hypothesized that this might be due to a blurring effect of time since menopause, and that body size could be demonstrated to have an effect on measured BMC and BMD, if this time effect could be eliminated. The results of this study, comprising 1625 early post-menopausal women studied at virtually the same time since menopause, confirm that this is the case. Body surface area was the parameter among conventional body size variables showing the highest correlation with BMC and BMD. It was clearly shown that low values of BMD were seen more often in the lowest than in the highest body surface area quartile. The difference between quartiles was statistically significant. Simpledivision of BMC by actual body surface area or division of BMD by thesquare root of body surface removed the uneven distribution between the body surface area quartiles for lumbar spine and femoral neck measurements, and reduced it at peripheral measuring sites. It is suggestedthat BMC and BMD of the lumbar spine and the femoral neck should be normalized as described to avoid overdiagnosis of osteoporosis in persons of petite body stature and underdiagnosis in tall ones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:18:05