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Titolo:
COMPLEMENT RECEPTOR-2 IN THE REGULATION OF THE IMMUNE-RESPONSE
Autore:
TOLNAY M; TSOKOS GC;
Indirizzi:
WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL,BLDG 40,RM 3078 WASHINGTON DC 20307 WALTER REED ARMY MED CTR,WALTER REED ARMY INST RES,DEPT CLIN PHYSIOL WASHINGTON DC 20307 UNIFORMED SERV UNIV HLTH SCI,DEPT MED BETHESDA MD 20814
Titolo Testata:
Clinical immunology and immunopathology (Print)
fascicolo: 2, volume: 88, anno: 1998,
pagine: 123 - 132
SICI:
0090-1229(1998)88:2<123:CRITRO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; HUMAN LYMPHOCYTES-B; FOLLICULAR DENDRITIC CELLS; SYSTEMIC LUPUS-ERYTHEMATOSUS; CALCIUM-BINDING PROTEIN; NF-KAPPA-B; T-DEPENDENT ANTIGEN; COBRA VENOM FACTOR; HUMAN CR-2 GENE; C3D RECEPTOR;
Keywords:
COMPLEMENT RECEPTOR 2; B LYMPHOCYTES; IMMUNE RESPONSE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
108
Recensione:
Indirizzi per estratti:
Citazione:
M. Tolnay e G.C. Tsokos, "COMPLEMENT RECEPTOR-2 IN THE REGULATION OF THE IMMUNE-RESPONSE", Clinical immunology and immunopathology (Print), 88(2), 1998, pp. 123-132

Abstract

Antigens coated with split products of C3, the result of complement activation, are capable of crosslinking the complement receptor 2 (CR2,CD21) and the antigen receptor on the surface of B cells simultaneously. This dual recognition leads to increased cell proliferation and differentiation and enhanced antibody production. CR2 is also consideredto be a regulator of the B cell response to antigen. In this review we summarize the biology of the CR2 and focus on its essential role in generating an effective B cell response to antigenic stimuli. The involvement of CR2 in the pathophysiology of infectious and autoimmune diseases is also discussed. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:52:01