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Titolo:
MOLECULAR EVOLUTION OF THE CECROPIN MULTIGENE FAMILY IN DROSOPHILA - FUNCTIONAL GENES VS. PSEUDOGENES
Autore:
RAMOSONSINS S; AGUADE M;
Indirizzi:
UNIV BARCELONA,FAC BIOL,DEPT GENET,DIAGONAL 645 E-08071 BARCELONA SPAIN UNIV BARCELONA,FAC BIOL,DEPT GENET E-08071 BARCELONA SPAIN
Titolo Testata:
Genetics
fascicolo: 1, volume: 150, anno: 1998,
pagine: 157 - 171
SICI:
0016-6731(1998)150:1<157:MEOTCM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-SEQUENCE VARIATION; POPULATION-GENETICS; NATURAL-SELECTION; MELANOGASTER; LOCUS; RECOMBINATION; POLYMORPHISM; SOFTWARE; HISTORY; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
S. Ramosonsins e M. Aguade, "MOLECULAR EVOLUTION OF THE CECROPIN MULTIGENE FAMILY IN DROSOPHILA - FUNCTIONAL GENES VS. PSEUDOGENES", Genetics, 150(1), 1998, pp. 157-171

Abstract

Approximately 4 kb of the Cecropin cluster region have been sequencedin nine lines of Drosophila melanogaster and one line of the sibling species D. simulans, D. mauritiana, and D. sechellia. This region includes three functional genes (CecA1, CecA2, and CecB), which are involved in the insect immune response, and two pseudogenes (Cec Psi 1 and Cec Psi 2). The level of silent polymorphism in the three Cec genes is rather high (0.028), and there is no excess of nonsynonymous polymorphism. There is no evidence of gene conversion in the history of these genes. The interspecific comparison has revealed that in the three species of the simulans cluster the CecA2 gene is partially deleted and has therefore lost its function and become a pseudogene; in each of the species, subsequent deletions have accumulated. Divergence estimates indicate that the Cec Psi 1 and Cec Psi 2 pseudogenes are highly diverged, both between themselves and relative to the other three Cec genes. However, both Cec Psi 1 and Cec Psi 2 have conserved transcriptional signals and splice sites, and they present an open reading frame; also, correctly spliced transcripts have been detected for both Cec Psi 1 and Cec Psi 2. The data support that these genes are either active genes with some null alleles or young pseudogenes.

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Documento generato il 04/12/20 alle ore 16:39:34