Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IMMUNE-MEDIATED AND INHERITED DEFENSES AGAINST FLAVIVIRUSES
Autore:
BRINTON MA; KURANE I; MATHEW A; ZENG LL; SHI PY; ROTHMAN A; ENNIS FA;
Indirizzi:
GEORGIA STATE UNIV,DEPT BIOL,POB 4010 ATLANTA GA 30302 UNIV MASSACHUSETTS,MED CTR,DEPT MED,DIV INFECT DIS & IMMUNOL WORCESTER MA 01655
Titolo Testata:
Clinical and diagnostic virology
fascicolo: 2-3, volume: 10, anno: 1998,
pagine: 129 - 139
SICI:
0928-0197(1998)10:2-3<129:IAIDAF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VALLEY ENCEPHALITIS-VIRUS; CYTOTOXIC T-LYMPHOCYTES; NONSTRUCTURAL PROTEIN NS1; WEST NILE VIRUS; B-CELL EPITOPES; DENGUE VIRUS; ENVELOPE PROTEIN; E-GLYCOPROTEIN; MONOCLONAL-ANTIBODIES; SYNTHETIC PEPTIDES;
Keywords:
FLAVIVIRUS; IMMUNE RESPONSE; FLAVIVIRAL T-CELL EPITOPE; FLAVIVIRAL B-CELL EPITOPE; GENETIC RESISTANCE; STRUCTURAL VIRAL PROTEIN; NONSTRUCTURAL VIRAL PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Brinton et al., "IMMUNE-MEDIATED AND INHERITED DEFENSES AGAINST FLAVIVIRUSES", Clinical and diagnostic virology, 10(2-3), 1998, pp. 129-139

Abstract

Background: Flavivirus infection elicits an abundant immune response in the host which is directed against a number of the viral proteins. Resistance to flavivirus-induced disease can also be controlled via a non-immune mechanism involving the product of a naturally occurring murine gene, Flv. Objectives: To review studies that have reported the mapping of epitopes on flavivirus proteins that elicit T- or B-cell immune responses in mice or humans and to discuss a possible mechanism for flavivirus-specific genetic resistance. Study design: Purified viralproteins and synthetic peptides were used to map B-cell epitopes. Purified proteins, vaccinia-expressed viral protein fragments and synthetic peptides were used to map T-cell epitopes. Congnic-resistant, C3H/RV and congenic susceptible, C3H/He mice and cell cultures were used tostudy the mechanism of genetic resistance to flavivirus infection. Results: T- and B-cell epitopes have been mapped to the E, NS1 and NS3 proteins of several flaviviruses. Immune responses to the C, PreM, NS2a, NS4a, and NS5 proteins have also been documented. Data suggest that the Fly gene product acts intracellularly to suppress the synthesis ofviral genomic RNA. Conclusions: Although flavivirus infection elicitsan abundant immune response, this response is not always rapid enoughto protect the host from developing encephalitis. During secondary infections both the humoral and cellular flavivirus-specific responses can confer protection. Dengue haemorrhagic fever (DHF) and dengue shocksyndrome (DSS) appear to be caused by an overly vigorous immune response. In genetically resistant animals reduced production of virus results in a slower spread of the infection, which in turn allows time forthe immune response to develop and to clear the infection before disease symptoms appear. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 13:48:09