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Titolo:
CORRELATION BETWEEN EXERCISE-INDUCED ISCHEMIC ST-SEGMENT DEPRESSION AND MYOCARDIAL BLOOD-FLOW QUANTIFIED BY POSITRON-EMISSION-TOMOGRAPHY
Autore:
WATANABE T; HARUMI K; AKUTSU Y; YAMANAKA H; MICHIHATA T; OKAZAKI O; KATAGIRI T;
Indirizzi:
UNIV TEXAS,SCH MED,DEPT INTERNAL MED,DIV CARDIOL,6431 FANNIN,MSB 6-039 HOUSTON TX 77030 FUJIGAOKA HOSP,DEPT INTERNAL MED 3,DIV CARDIOL TOKYO JAPAN SHOWA UNIV,SCH MED,DEPT SURG 1 YOKOHAMA KANAGAWA JAPAN UNIV UTAH,CVRTI SALT LAKE CITY UT 00000
Titolo Testata:
The American heart journal
fascicolo: 3, volume: 136, anno: 1998,
pagine: 533 - 542
SICI:
0002-8703(1998)136:3<533:CBEISD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMERICAN-HEART-ASSOCIATION; CORONARY-ARTERY DISEASE; CARDIOLOGY TASK-FORCE; CLINICAL-SIGNIFICANCE; TL-201 SCINTIGRAPHY; N-13 AMMONIA; INFARCTION; GUIDELINES; ANGIOGRAPHY; OCCLUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T. Watanabe et al., "CORRELATION BETWEEN EXERCISE-INDUCED ISCHEMIC ST-SEGMENT DEPRESSION AND MYOCARDIAL BLOOD-FLOW QUANTIFIED BY POSITRON-EMISSION-TOMOGRAPHY", The American heart journal, 136(3), 1998, pp. 533-542

Abstract

Background Ischemic ST-segment depression (horizontal or downsloping)is the most common manifestation of exercise-induced myocardial ischemia. The mechanisms responsible for these types of ST-segment depression are largely unknown. We investigated the relation of these 2 types of exercise-induced ST-segment depression to changes in regional myocardial blood flow (RMBF) by using exercise positron emission tomography(PET). Methods and Results The RMBF was measured with nitrogen-13 ammonia PET both at rest and during low-level supine bicycle exercise in 27 patients with angiographically proven coronary artery disease and in 6 healthy volunteers. ST-segment depression was measured from the isoelectric PR segment 80 ms after the J point. Exercise-induced horizontal ST-segment depression greater than or equal to 0.1 mV was observedin 9 patients and downsloping depression greater than or equal to 0.1mV was observed in 18 patients. Multivessel disease was more frequentand areas of exercise-induced ischemia were larger in patients with downsloping depression than inpatients with horizontal depression (P < .02, P < .05). in patients with horizontal ST-segment depression, RMBFin ischemic areas and in surrounding areas increased by a similar amount(31% +/- 29% and 32% +/- 16%) with exercise. In patients with downsloping ST-segment depression, RMBF was unchanged or decreased in ischemic areas (10% +/- 24%) but increased in surrounding areas (46% +/- 27%) with exercise. in healthy volunteers, RMBF increased in all areas (56% +/- 30%) with exercise. Conclusions Compared with horizontal changes in ST-segment morphology, downsloping changes may better indicate severe ischemia and greater differences in the increase of blood flow with exercise in the ischemic myocardium and in the surrounding areas.

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Documento generato il 25/01/20 alle ore 00:28:23