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Titolo:
BIOLOGICAL ACTION OF LEPTIN AS AN ANGIOGENIC FACTOR
Autore:
SIERRAHONIGMANN MR; NATH AK; MURAKAMI C; GARCIACARDENA G; PAPAPETROPOULOS A; SESSA WC; MADGE LA; SCHECHNER JS; SCHWABB MB; POLVERINI PJ; FLORESRIVEROS JR;
Indirizzi:
YALE UNIV,SCH MED,BOYER CTR MOL MED,333 CEDAR ST NEW HAVEN CT 06536 UNIV MICHIGAN,SCH DENT,DEPT ORAL MED PATHOL SURG ANN ARBOR MI 48109 BAYER CORP,INST METAB DISORDERS W HAVEN CT 06516
Titolo Testata:
Science
fascicolo: 5383, volume: 281, anno: 1998,
pagine: 1683 - 1686
SICI:
0036-8075(1998)281:5383<1683:BAOLAA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; OB PROTEIN; OBESE GENE; CELLS; RECEPTOR; MICE; EXPRESSION; ACTIVATION; ADIPOSITY; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Sierrahonigmann et al., "BIOLOGICAL ACTION OF LEPTIN AS AN ANGIOGENIC FACTOR", Science, 281(5383), 1998, pp. 1683-1686

Abstract

Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown thatOB-Rb is also expressed in human vasculature and in primary cultures oi human endothelial coils, In vitro and in vivo assays revealed that Leptin has angiogenic activity. In vivo, Leptin induced neovascularization in corneas from normal rats but not in corneas from fa/fa Zucker rats, which Lack functional Leptin receptors. These observations indicate that the vascular endothelium is a target for Leptin and suggest aphysiological mechanism whereby Leptin-induced angiogenesis may facilitate increased energy expenditure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:17:10