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Titolo:
PROCALCITONIN - A NEW DIAGNOSTIC PARAMETER FOR SEVERE INFECTION AND SEPSIS
Autore:
OBERHOFFER M; KARZAI W; MEIERHELLMANN A; REINHART K;
Indirizzi:
UNIV JENA,KLIN ANASTHESIOL & INTENS THERAPIE D-07743 JENA GERMANY UNIV JENA KLINIKUM,KLIN ANASTHESIOL & INTENS THERAPIE JENA GERMANY
Titolo Testata:
Anaesthesist
fascicolo: 7, volume: 47, anno: 1998,
pagine: 581 - 587
SICI:
0003-2417(1998)47:7<581:P-ANDP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
GER
Soggetto:
MULTIPLE ORGAN FAILURE; C-REACTIVE PROTEIN; SERUM PROCALCITONIN; SEPTIC SHOCK; BACTERIAL-INFECTION; ACUTE-PANCREATITIS; THERMAL-INJURY; ENDOTOXIN; CYTOKINES; MARKER;
Keywords:
PROCALCITONIN; CYTOKINE; INFECTION; SEPSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
M. Oberhoffer et al., "PROCALCITONIN - A NEW DIAGNOSTIC PARAMETER FOR SEVERE INFECTION AND SEPSIS", Anaesthesist, 47(7), 1998, pp. 581-587

Abstract

Procalcitonin (PCT),a glycoprotein consisting of 116 amino acids, hasbeen proposed as a new marker of severe infection. The site of production under this condition remains unknown. The serum PCT concentrationis determined by an immunoluminometric assay of 40 mu l serum or plasma requiring approximately two hours. Elevations of PCT are for instance associated with levels of lipopolysaccharide and the cytokines TNF-alpha and IL-6. Bacterial, parasitic or fungal infections developing septic complications in contrast to local infections, often show valuesexceeding 2 ng/ml. The specificity of the parameter in this context increases with its concentrations. Therapeutic actions that confine theinfection locally are reflected by a decrease of the PCT value. PCT may be elevated within the first days after extended surgery or polytrauma, in some malignancies, heatstroke and during treatment of some hematologic diseases without an existing sepsis or severe infection. Previous studies indicate certain benefits of PCT compared to traditional markers of inflammation or sepsis, where the ability to indicate a generalized infection is the primary advantage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:26:11