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Titolo:
SELECTIVE SEROTONIN REUPTAKE INHIBITORS REDUCE THE SPONTANEOUS ACTIVITY OF DOPAMINERGIC-NEURONS IN THE VENTRAL TEGMENTAL AREA
Autore:
DIMASCIO M; DIGIOVANNI G; DIMATTEO V; PRISCO S; ESPOSITO E;
Indirizzi:
IST RIC FARMACOL MARIO NEGRI,CONSORZIO MARIO NEGRI SUD I-66030 SANTA MARIA IMBAR ITALY IST RIC FARMACOL MARIO NEGRI,CONSORZIO MARIO NEGRI SUD I-66030 SANTA MARIA IMBAR ITALY
Titolo Testata:
Brain research bulletin
fascicolo: 6, volume: 46, anno: 1998,
pagine: 547 - 554
SICI:
0361-9230(1998)46:6<547:SSRIRT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; FORCED SWIMMING TEST; IN-VIVO; RECEPTOR ANTAGONIST; INDUCED AKATHISIA; EXTRAPYRAMIDAL SYMPTOMS; EXTRACELLULAR SEROTONIN; ANTIDEPRESSANT DRUGS; NUCLEUS ACCUMBENS; MAJOR DEPRESSION;
Keywords:
PAROXETINE; SERTRALINE; FLUVOXAMINE; DOPAMINERGIC NEURONS; VENTRAL TEGMENTAL AREA; ELECTROPHYSIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
M. Dimascio et al., "SELECTIVE SEROTONIN REUPTAKE INHIBITORS REDUCE THE SPONTANEOUS ACTIVITY OF DOPAMINERGIC-NEURONS IN THE VENTRAL TEGMENTAL AREA", Brain research bulletin, 46(6), 1998, pp. 547-554

Abstract

Electrophysiological techniques were used to study the effects of paroxetine, sertraline, and fluvoxamine on the basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of rats. Acute i.v. administrations of paroxetine (20-1280 mu g/kg), sertraline (20-1280 mug/kg), and fluvoxamine (20-1280 mu g/kg) caused a slight but significant reduction in the firing rate of the VTA dopaminergic cells studied. Paroxetine produced a maximal inhibitory effect of 10 +/- 11% at thecumulative dose of 160 mu g/kg. Sertraline induced a dose-related inhibition of VTA dopaminergic neurons, which reached its maximum (10 +/-7%) at the cumulative dose of 1280 mu g/kg. The effect of fluvoxamineon the basal firing rate of VTA dopaminergic neurons was more pronounced as compared to that of paroxetine and sertraline, in that it produced a maximal inhibition of 17 +/- 12% at the cumulative dose of 1280 mu g/kg. Acute i.v. injections of paroxetine (20-1280 mu g/kg), sertraline (20-1280 mu g/kg), and fluvoxamine (20-5120 mu g/kg) caused a dose-dependent decrease in the basal firing rate of serotonergic neurons in the dorsal raphe nucleus (DRN), Paroxetine and sertraline stopped the spontaneous firing of serotonergic neurons at the cumulative dose of 1280 mu g/kg, whereas fluvoxamine reached the same effect only at the cumulative dose of 5120 mu g/kg, Pretreatment with the 5-HT1A receptor antagonist tertatolol (1 mg/kg, i.v.) reduced the inhibitory effects of paroxetine, fluvoxamine, and sertraline on the basal activity of serotonergic neurons in the DRN, Administration of tertatolol induced a 15-fold increase in the ED50 for fluvoxamine. The antagonistic effect of tertatolol was much less evident in blocking the inhibitory action exerted by paroxetine and sertraline on the activity of serotonergicneurons, Pretreatment with tertatolol (1 mg/kg, i.v.) potentiated theinhibitory effect of fluvoxamine on the basal activity of VTA dopaminergic neurons. Tertatolol did not affect the inhibitory action exertedby paroxetine and sertraline on these neurons. It is concluded that inhibition of the basal firing rate of dopaminergic neurons in the VTA is a common characteristic of selective serotonin reuptake inhibitors (SSRIs). The effects of SSRIs on VTA dopaminergic cell activity might be relevant for their therapeutic action and may explain the origin ofthe reported cases of akathisia, (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:30:38