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Titolo:
INTERACTIONS BETWEEN SULPIRIDE INFUSIONS WITHIN THE PERIFORNICAL REGION OF THE LATERAL HYPOTHALAMUS AND THE NUCLEUS-ACCUMBENS ON MEASURES OF LOCOMOTOR-ACTIVITY AND CONDITIONED PLACE PREFERENCE
Autore:
MORUTTO SL; PHILLIPS GD;
Indirizzi:
UNIV YORK,DEPT PSYCHOL YORK YO1 5DD N YORKSHIRE ENGLAND UNIV YORK,DEPT PSYCHOL YORK YO1 5DD N YORKSHIRE ENGLAND
Titolo Testata:
Behavioural pharmacology
fascicolo: 4, volume: 9, anno: 1998,
pagine: 345 - 355
SICI:
0955-8810(1998)9:4<345:IBSIWT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; HYDROXYLASE-IMMUNOREACTIVE NEURONS; DOPAMINE-RECEPTOR SUBTYPES; BASOLATERAL AMYGDALA; CROSS-SENSITIZATION; RAT; AMPHETAMINE; STRIATUM; SYSTEM; INNERVATION;
Keywords:
PERIFORNICAL REGION OF THE LATERAL HYPOTHALAMUS; NUCLEUS ACCUMBENS; DOPAMINE; ACTIVITY; CONDITIONED PLACE PREFERENCE; SULPIRIDE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Morutto e G.D. Phillips, "INTERACTIONS BETWEEN SULPIRIDE INFUSIONS WITHIN THE PERIFORNICAL REGION OF THE LATERAL HYPOTHALAMUS AND THE NUCLEUS-ACCUMBENS ON MEASURES OF LOCOMOTOR-ACTIVITY AND CONDITIONED PLACE PREFERENCE", Behavioural pharmacology, 9(4), 1998, pp. 345-355

Abstract

There is growing evidence of a functionally significant link between the perifornical region of the lateral hypothalamus (PFH) and the mesoaccumbens dopamine projection. The present study assessed the ability of intra-accumbens dopamine receptor blockade, firstly to impair the locomotor stimulant properties of intra-PFH sulpiride, and secondly theability of intra-PFH sulpiride to support a conditioned place preference. Locomotor activity and conditioned place preference training wereassessed using an apparatus consisting of three distinctive compartments. Following a pre-exposure session in which groups showed equivalent preference for the three compartments, conditioned place preference training was carried out over five drug (0, 0.03 or 0.1 mu g intra-accumbens sulpiride; 0 or 5 mu g intra-PFH sulpiride) and five vehicle sessions. For each animal, drug and vehicle treatments were randomly paired with one of the two outermost compartments. Locomotor activity wasmonitored during each session. Intra-PFH sulpiride alone increased locomotor activity during later sessions, and this gradual increase in locomotor response, relative to vehicle infusions, was blocked by intra-accumbens sulpiride co-infusion. On the final drug-free test day for conditioned place preference, animals were again permitted free accessto all three compartments, and the time spent in each was compared with that on initial exposure. Intra-PFH sulpiride alone supported a conditioned place preference. Intra-accumbens sulpiride was without intrinsic effect, but nevertheless blocked the ability of intra-PFH sulpiride to support a conditioned place preference. These data provide further support for a functionally significant link between the PFH and mesoaccumbens dopamine projection, with regard to the locomotor stimulantproperties and ability of intra-PFH infusions of sulpiride to supporta conditioned place preference. Behav Pharmacol 1998; 9:345-355 (C) 1998 Lippincott-Raven Publishers.

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Documento generato il 30/03/20 alle ore 12:05:09