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Titolo:
PHARMACOLOGICAL CONTROL OF FACILITATORY I-WAVE INTERACTION IN THE HUMAN MOTOR CORTEX - A PAIRED TRANSCRANIAL MAGNETIC STIMULATION STUDY
Autore:
ZIEMANN U; TERGAU F; WISCHER S; HILDEBRANDT J; PAULUS W;
Indirizzi:
NINCDS,HUMAN CORT PHYSIOL UNIT,NIH,BLDG 10,ROOM 5N242,10 CTR DR BETHESDA MD 20982 UNIV GOTTINGEN,DEPT CLIN NEUROPHYSIOL D-37075 GOTTINGEN GERMANY
Titolo Testata:
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
fascicolo: 4, volume: 109, anno: 1998,
pagine: 321 - 330
SICI:
0924-980X(1998)109:4<321:PCOFII>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; GABA-MEDIATED INHIBITION; CHANDELIER CELL AXONS; HUMAN CEREBRAL-CORTEX; ELECTRICAL-STIMULATION; EVOKED-POTENTIALS; CORTICOSPINAL VOLLEYS; CORTICAL EXCITABILITY; CORTICOCORTICAL INHIBITION; INTRACORTICAL INHIBITION;
Keywords:
PAIRED TRANSCRANIAL MAGNETIC STIMULATION; HUMAN MOTOR CORTEX; I-WAVES; MOTOR EVOKED POTENTIAL; ANTIEPILEPTIC DRUGS; GAMMA-AMINOBUTYRIC ACID (GABA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
U. Ziemann et al., "PHARMACOLOGICAL CONTROL OF FACILITATORY I-WAVE INTERACTION IN THE HUMAN MOTOR CORTEX - A PAIRED TRANSCRANIAL MAGNETIC STIMULATION STUDY", ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 109(4), 1998, pp. 321-330

Abstract

A novel paired transcranial magnetic stimulation (TMS) paradigm with a suprathreshold first and a subthreshold second stimulus was used in healthy volunteers to investigate the acute effects of a single oral dose of various CNS-active drugs on short-interval motor evoked potential (MEP) facilitation. MEPs were recorded from the relaxed abductor digiti muscle. Three peaks of MEP facilitation were consistently observed at interstimulus intervals of 1.1-1.5 ms, 2.3-2.7 ms, and 3.9-4.5 ms. The size of these MEP peaks was transiently suppressed by drugs which enhance gamma-aminobutyric acid (GABA) function in the neocortex (lorazepam, vigabatrin, phenobarbital, ethanol), while the GABA-B receptor agonist baclofen, anti-glutamate drugs (gabapentin, memantine), and sodium channel blockers (carbamazepine, lamotrigine) had no effect. The interstimulus intervals effective for the production of the MEP peaks remained unaffected by all drugs. The MEP peaks are thought to be due to a facilitatory interaction of I-(indirect) waves in the motor cortex. Therefore, the present results indicate that the production of I-waves is primarily controlled by GABA related neuronal circuits. The potential relevance of this nan-invasive paired TMS protocol for the investigation of I-waves in patients with neurological disease will be discussed. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 05/04/20 alle ore 04:10:52