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Titolo:
THE LUNATIC FRINGE GENE IS A TARGET OF THE MOLECULAR CLOCK LINKED TO SOMITE SEGMENTATION IN AVIAN EMBRYOS
Autore:
MCGREW MJ; DALE JK; FRABOULET S; POURQUIE O;
Indirizzi:
UNIV MEDITERRANEE AP DE MARSEILLE,LAB GENET & PHYSIOL DEV,DEV BIOL INST MARSEILLE,CNRS,INSERM F-13288 MARSEILLE 09 FRANCE UNIV MEDITERRANEE AP DE MARSEILLE,LAB GENET & PHYSIOL DEV,DEV BIOL INST MARSEILLE,CNRS,INSERM F-13288 MARSEILLE 09 FRANCE
Titolo Testata:
Current biology
fascicolo: 17, volume: 8, anno: 1998,
pagine: 979 - 982
SICI:
0960-9822(1998)8:17<979:TLFGIA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELTA-HOMOLOG; CHICK HOMOLOG; NOTCH; EXPRESSION; SOMITOGENESIS; NEUROGENESIS; SERRATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Mcgrew et al., "THE LUNATIC FRINGE GENE IS A TARGET OF THE MOLECULAR CLOCK LINKED TO SOMITE SEGMENTATION IN AVIAN EMBRYOS", Current biology, 8(17), 1998, pp. 979-982

Abstract

The most obvious segments of the vertebrate embryo are the trunk mesodermal somites which give rise to the segmented vertebral column and the skeletal muscles of the body. Mechanistic insights into vertebrate somitogenesis have recently been gained from observations of rhythmic expression of the avian hairy-related gene (c-hairy1) in chick presomitic mesoderm (PSM), suggesting the existence of a molecular clock linked to somite segmentation ([1]; reviewed in [2]), Here, we show that lunatic Fringe (IFng), a vertebrate homolog of the Drosophila Fringe gene, is also expressed rhythmically in PSM, The PSM expression of IFng was observed as coordinated pulses of mRNA resembling the expression of c-hairy1, We show that c-hairy1 and IFng expression in the PSM are coincident, indicating that both genes are responding to the same segmentation clock. The genes were found to differ in their regulation, however; in contrast to c-hairy1, IFng mRNA oscillations required continued protein synthesis, suggesting that IFng could be acting downstream of c-hairy1 in the clock mechanism. In Drosophila, Fringe has been shown to play a role in modulating Notch-Delta signalling [3,4], a pathway which in vertebrates has been implicated in defining somite boundaries [5-9]. These observations place the segmentation clock upstream of the Notch-Delta pathway during vertebrate somitogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:19:17