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Titolo:
LINKAGE AND ASSOCIATION OF ADRENERGIC AND DOPAMINE-RECEPTOR GENES IN THE DISTAL PORTION OF THE LONG ARM OF CHROMOSOME-5 WITH SYSTOLIC BLOOD-PRESSURE VARIATION
Autore:
KRUSHKAL J; XIONG MM; FERRELL R; SING CF; TURNER ST; BOERWINKLE E;
Indirizzi:
UNIV TEXAS,HLTH SCI CTR,INST MOL MED HOUSTON TX 77225 UNIV TEXAS,HLTH SCI CTR,INST MOL MED HOUSTON TX 77225 UNIV TEXAS,HLTH SCI CTR,CTR HUMAN GENET HOUSTON TX 77225 UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT HUMAN GENET PITTSBURGH PA 15261 UNIV MICHIGAN,DEPT HUMAN GENET ANN ARBOR MI 48109 MAYO CLIN & MAYO FDN,DIV HYPERTENS & INTERNAL MED ROCHESTER MN 55905
Titolo Testata:
Human molecular genetics (Print)
fascicolo: 9, volume: 7, anno: 1998,
pagine: 1379 - 1383
SICI:
0964-6906(1998)7:9<1379:LAAOAA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSMISSION/DISEQUILIBRIUM TEST TDT; QUANTITATIVE TRAIT LOCI; RADIATION HYBRID MAP; DISCORDANT SIB PAIRS; ESSENTIAL-HYPERTENSION; DISEQUILIBRIUM; HUMAN-CHROMOSOME-5; REGION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J. Krushkal et al., "LINKAGE AND ASSOCIATION OF ADRENERGIC AND DOPAMINE-RECEPTOR GENES IN THE DISTAL PORTION OF THE LONG ARM OF CHROMOSOME-5 WITH SYSTOLIC BLOOD-PRESSURE VARIATION", Human molecular genetics (Print), 7(9), 1998, pp. 1379-1383

Abstract

Elevated blood pressure is an important risk factor for renal-, cerebro- and cardiovascular diseases. We used an efficient discordant sib-pair ascertainment scheme to investigate the impact of the distal end of the long arm of human chromosome 5 (chromosomal region 5q31.1-qter) containing genes for the alpha(1B) and beta(2) adrenergic receptors and the dopamine receptor type 1A on variation of systolic blood pressure in young Caucasians. We measured eight highly polymorphic markers spanning this positional candidate gene-rich region in 427 individuals from 55 three-generation pedigrees containing 69 discordant sibling pairs, and calculated multipoint identity by descent (MIBD) probabilities. The results of genetic linkage and association tests indicate that the region between markers D5S2093 and D5S462 is significantly linked to one or more polymorphic genes influencing interindividual variation in systolic blood pressure levels. Since the alpha(1B) adrenergic receptor and dopamine receptor type 1A genes are located close to these markers, these data suggest that genetic variation in one or both of these G protein-coupled receptors, which participate in the control of vascular tone, plays an important role in influencing interindividual variation in systolic blood pressure levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:41:37