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Titolo:
SCHIZOPHRENIA SUSCEPTIBILITY LOCI ON CHROMOSOMES 13Q32 AND 8P21
Autore:
BLOUIN JL; DOMBROSKI BA; NATH SK; LASSETER VK; WOLYNIEC PS; NESTADT G; THORNQUIST M; ULLRICH G; MCGRATH J; KASCH L; LAMACZ M; THOMAS MG; GEHRIG C; RADHAKRISHNA U; SNYDER SE; BALK KG; NEUFELD K; SWARTZ KL; DEMARCHI N; PAPADIMITRIOU GN; DIKEOS DG; STEFANIS CN; CHAKRAVARTI A; CHILDS B; HOUSMAN DE; KAZAZIAN HH; ANTONARAKIS SE; PULVER AE;
Indirizzi:
JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI BALTIMORE MD 21231 JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI BALTIMORE MD 21231 UNIV GENEVA,SCH MED,DIV MED GENET CH-1211 GENEVA SWITZERLAND UNIV GENEVA,HOP CANTONAL CH-1211 GENEVA SWITZERLAND UNIV PENN,DEPT GENET PHILADELPHIA PA 19104 CASE WESTERN RESERVE UNIV,DEPT GENET CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,CTR HUMAN GENET CLEVELAND OH 44106 UNIV HOSP CLEVELAND CLEVELAND OH 44106 UNIV NAPLES 2,INST PSICHIATRIA I-80138 NAPLES ITALY UNIV ATHENS,EGINIT HOSP,MENTAL HLTH RES INST GR-11528 ATHENS GREECE MIT,CTR CANC RES CAMBRIDGE MA 02139
Titolo Testata:
Nature genetics
fascicolo: 1, volume: 20, anno: 1998,
pagine: 70 - 73
SICI:
1061-4036(1998)20:1<70:SSLOC1>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKAGE ANALYSIS; VULNERABILITY LOCUS; GENETIC-LINKAGE; SUGGESTIVE EVIDENCE; POTENTIAL LINKAGE; FAMILIAL RISK; HUMAN GENOME; HETEROGENEITY; IDENTIFY; SUPPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Blouin et al., "SCHIZOPHRENIA SUSCEPTIBILITY LOCI ON CHROMOSOMES 13Q32 AND 8P21", Nature genetics, 20(1), 1998, pp. 70-73

Abstract

Schizophrenia is a common disorder characterized by psychotic symptoms; diagnostic criteria have been established(1). Family, twin and adoption studies suggest that both genetic and environmental factors influence susceptibility (heritability is approximately 71%; ref. 2), however, little is known about the aetiology of schizophrenia. Clinical andfamily studies suggest aetiological heterogeneity(3-6). Previously, we reported that regions on chromosomes 22, 3 and 8 may be associated with susceptibility to schizophrenia(7-8), and collaborations provided some support for regions on chromosomes 8 and 22 (refs 9-13). We present here a genome-wide scan for schizophrenia susceptibility loci (SSL)using 452 microsatellite markers on 54 multiplex pedigrees. Non-parametric linkage (NPL) analysis provided significant evidence for an SSL on chromosome 13q32 (NPL score=4.18; P=0.00002), and suggestive evidence for another SSL on chromosome 8p21-22 (NPL=3.64; P=0.0001). Parametric linkage analysis provided additional support for these SSL. Linkage evidence at chromosome 8 is weaker than that at chromosome 13, so itis more probable that chromosome 8 may be a false positive linkage. Additional putative SSL were noted on chromosomes 14q13 (NPL=2.57: P=0.005), 7q11 (NPL=2.50, P=0.007) and 22q11 (NPL=2.42, P=0.009). Verification of suggestive SSL on chromosomes 13q and 8p was attempted in a follow-up sample of 54 multiplex pedigrees. This analysis confirmed the SSL in 13q14-q33 (NPL=2.36, P=0.007) and supported the SSL in 8p22-p21(NPL=1.95, P=0.023).

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Documento generato il 09/07/20 alle ore 14:12:17