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Titolo:
METHADONE-MAINTENANCE IN PREGNANCY - A REAPPRAISAL
Autore:
BROWN HL; BRITTON KA; MAHAFFEY D; BRIZENDINE E; HIETT AK; TURNQUEST MA;
Indirizzi:
WISHARD MEM HOSP,DEPT OBSTET & GYNECOL,1001 W 10TH ST INDIANAPOLIS IN46202 INDIANA UNIV,MED CTR,DEPT OBSTET & GYNECOL INDIANAPOLIS IN 00000 INDIANA UNIV,MED CTR,DIV BIOSTAT INDIANAPOLIS IN 00000
Titolo Testata:
American journal of obstetrics and gynecology
fascicolo: 2, volume: 179, anno: 1998,
pagine: 459 - 463
SICI:
0002-9378(1998)179:2<459:MIP-AR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEONATAL WITHDRAWAL; CONSEQUENCES; DRUG; EXPOSURE; PROGRAM; INFANTS; COCAINE; DOSAGE; FETAL;
Keywords:
METHADONE; ILLICIT DRUG USE; NEONATAL OUTCOME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H.L. Brown et al., "METHADONE-MAINTENANCE IN PREGNANCY - A REAPPRAISAL", American journal of obstetrics and gynecology, 179(2), 1998, pp. 459-463

Abstract

OBJECTIVE: The purpose of this study is to evaluate women receiving methadone maintenance during pregnancy. STUDY DESIGN: Thirty-two pregnancies in women receiving methadone maintenance were matched by gestational age to women with a positive urine screen for cocaine at deliveryand to drug-free controls. Pregnancy outcome variables were compared,including birth weight and neonatal morbidity. Analysis was by chi(2)and t test with significance set at .05. RESULTS: Birth weight of methadone-exposed infants was 2748 g versus 2925 g for cocaine and 3032 gfor controls, P = not significant. Birth weight comparison with a 50-mg maternal methadone cutoff dose was not different. A head circumference for methadone infants of 32.4 +/- 4.7 cm was significantly less than controls, 33.5 +/- 4.0 cm, P <.04, but not different from infants of cocaine users, 32.8 +/- 3.1 cm. Women using cocaine had a significantly higher incidence of meconium in labor compared with methadone and controls. Of women taking methadone 27 of 32 (84.3%) were positive forother drugs of abuse in the last screen before or at delivery. Cocaine 12 of 32 (37.5%), other opiates 13 of 32 (40.6%), and marijuana 14 of 32 (43.7%) were the most prevalent. Neonatal withdrawal occurred in 23 of 32 (72%) women taking methadone. The neonates of women using <50mg of methadone were as likely to withdraw as those women using greater than or equal to 50 mg, 61.5% versus 79.0%, P not significant. Three neonates in the methadone group (9.3%) had major congenital anomalies, with 2 of the 3 (66.6%) resulting in mortality CONCLUSIONS: Birth outcome is not significantly different between methadone and cocaine users. Women receiving methadone maintenance are likely to abuse other illicit drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:22:00