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Titolo:
SELECTIVE CHANGES IN AMPA RECEPTORS IN RABBIT CEREBELLUM FOLLOWING CLASSICAL-CONDITIONING OF THE EYELID-NICTITATING MEMBRANE RESPONSE
Autore:
HAUGE SA; TRACY JA; BAUDRY M; THOMPSON RF;
Indirizzi:
UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089 UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089 INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI BLOOMINGTON IN 47401
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 803, anno: 1998,
pagine: 9 - 18
SICI:
0006-8993(1998)803:1-2<9:SCIARI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; ACID BINDING-SITES; PURKINJE-CELLS; GLUTAMATE RECEPTORS; MUTANT MICE; RAT-BRAIN; INTERPOSITUS NUCLEUS; EXCITATORY CURRENTS; MOTOR COORDINATION; SYNAPTIC CURRENTS;
Keywords:
CLASSICAL CONDITIONING; NICTITATING MEMBRANE; LPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID; 6-CYANO-7-NITROQUINOXALINE-2,3-DION; QUISQUALATE RECEPTOR; CEREBELLUM; AUTORADIOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Hauge et al., "SELECTIVE CHANGES IN AMPA RECEPTORS IN RABBIT CEREBELLUM FOLLOWING CLASSICAL-CONDITIONING OF THE EYELID-NICTITATING MEMBRANE RESPONSE", Brain research, 803(1-2), 1998, pp. 9-18

Abstract

lpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors are critically involved in several forms of synaptic plasticity proposed to be neural substrates for learning and memory, e.g., long-term potentiation and long-term depression (LTD). The present study was designed to determine changes in cerebellar AMPA receptors following classical conditioning of the eyeblink-nictitating membrane response (NMR) in the rabbit. Quantitative autoradiography was used to assess changes in ligand binding properties of cerebellar AMPA receptors following NMR conditioning elicited by pairing electrical stimulation of the pontine nuclei with an ah-puff to the eye. [H-3]AMPA and [H-3]-6-cyano-7-nitroquinoxaline-2,3-dion (CNQX) binding were determined following preincubation of frozen-thawed brain tissue sections at 0 or 35 degreesC. With 0 degrees C preincubation, no significant differences in [H-3]AMPA binding to cerebellar AMPA receptors were seen between any of the experimental groups tested. In contrast, preincubation at 35 degreesC revealed significant decreases in [H-3]AMPA binding to the trained side of the cerebellar cortex resulting from paired presentations of the conditioned and the unconditioned stimuli, while unpaired presentations of the stimuli resulted in no significant effect. With 35 degreesC preincubation, there were no significant differences in [H-3]CNQX binding between any of the experimental groups and no significant differences in [H-3]AMPA binding in the untrained side of the cerebellum. These results indicate that NMR conditioning is associated with a selective modification of AMPA-receptor properties in brain structures involved in the storage of the associative memory. Furthermore, they support the hypothesis that cerebellar LTD, resulting from decreased synaptic efficacy at parallel fiber-Purkinje cell synapses mediated by a change in AMPA-receptor properties, is a form of synaptic plasticity thatsupports this type of learning. (C) 1998 Published by Elsevier Science B,V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:41:01