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Titolo:
RAPID EFFECTS OF KAINATE ADMINISTRATION ON ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC-ACID (AMPA) RECEPTOR PROPERTIES IN RAT HIPPOCAMPUS
Autore:
STANDLEY S; BAUDRY M;
Indirizzi:
UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Experimental neurology
fascicolo: 2, volume: 152, anno: 1998,
pagine: 208 - 213
SICI:
0014-4886(1998)152:2<208:REOKAO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT PROTEIN-KINASE; INDUCED SEIZURE ACTIVITY; KAINIC ACID; GLUTAMATE RECEPTORS; GENE-EXPRESSION; PHOSPHORYLATION; EPILEPSY; NEURONS; SUBUNIT; BRAIN;
Keywords:
GLUTAMATE; HIPPOCAMPUS; RECEPTORS; SEIZURE; TURNOVER; PLASTICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S. Standley e M. Baudry, "RAPID EFFECTS OF KAINATE ADMINISTRATION ON ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC-ACID (AMPA) RECEPTOR PROPERTIES IN RAT HIPPOCAMPUS", Experimental neurology, 152(2), 1998, pp. 208-213

Abstract

We investigated changes in AMPA receptor properties in rat hippocampus 5 h after systemic kainate administration. Quantitative [H-3]AMPA autoradiography and Western blot analysis of receptor subunits GluR1-3 in different subcellular fractions were used to evaluate possible alterations in binding characteristics and immunological properties of the receptors in synaptic and nonsynaptic fractions. Both ligand-binding and Western blots revealed significant changes in binding and immunological properties of nonsynaptic receptors but relatively smaller changes in synaptic receptors 5 h after kainate administration. GluR2/3 showed a greater relative change in the synaptic receptor population compared to GluR1, suggesting either a shift in subunit composition of AMPAreceptors or the formation of a synaptic subpopulation of AMPA receptors with truncated C-terminal domain of GluR1 subunits. The effects ofkainic acid were blocked by cycloheximide treatment indicating that the changes were due at least in part to increased synthesis of AMPA receptor subunits. The results indicate that excessive synaptic activityproduces rapid changes in both synaptic and nonsynaptic AMPA receptorproperties. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:33:59