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Titolo:
EXPRESSION OF ENDOTHELIN-1 AND EFFECTS OF AN ENDOTHELIN RECEPTOR ANTAGONIST, TAK-044, AT REPERFUSION AFTER COLD PRESERVATION IN A CANINE LUNG TRANSPLANTATION MODEL
Autore:
MIZUTANI H; MINAMOTO K; AOE M; YAMASHITA M; DATE H; ANDOU A; SHIMIZU N;
Indirizzi:
OKAYAMA UNIV,FAC MED,DEPT SURG,2-5-1 SHIKATA CHO OKAYAMA 700 JAPAN
Titolo Testata:
The Journal of heart and lung transplantation
fascicolo: 8, volume: 17, anno: 1998,
pagine: 835 - 845
SICI:
1053-2498(1998)17:8<835:EOEAEO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY-HYPERTENSION; VASOCONSTRICTOR PEPTIDE; HIGHLY POTENT; PLASMA; PHARMACOLOGY; RATS; RECIPIENTS; CELLS; ET(A); ET(B);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
H. Mizutani et al., "EXPRESSION OF ENDOTHELIN-1 AND EFFECTS OF AN ENDOTHELIN RECEPTOR ANTAGONIST, TAK-044, AT REPERFUSION AFTER COLD PRESERVATION IN A CANINE LUNG TRANSPLANTATION MODEL", The Journal of heart and lung transplantation, 17(8), 1998, pp. 835-845

Abstract

Background: Rapid increase of pulmonary vascular resistance (PVR) early after reperfusion remains a major issue in clinical lung transplantation. A potent vasoconstrictor peptide, endothelin-l plays an important role in various pulmonary pathophysiologic conditions and might induce increased PVR. We investigated the expression and influence of endothelin-l, and the effects of an ETA and ETB nonselective endothelin receptor antagonist, TAK-044, at reperfusion after cold preservation ina canine lung transplantation model. Methods: Left single lung allotransplantation procedures were performed in three groups of animals. Ingroup I (n = 5) lungs were preserved for 12 hours; in group II (n = 5) lungs were preserved for 18 hours; and in group III (n = 6) lungs were also preserved for 18 hours, and TAK-044 (5 mg/kg) was administeredjust before reperfusion. All donor lungs were flushed and preserved with low-potassium dextran glucose solution at 4 degrees C. Results: Six hours after reperfusion, arterial oxygen tension (mm Hg, inspired oxygen fraction = 1.0) was 512.9 +/- 34.7 in group I, 152.4 +/- 46.7 in group II, and 509.6 +/- 29.0 in group III; PVR index (dyne sec cm(-5) m(2)) was 1130 +/- 142 in group I, 1820 +/- 142 in group II, and 1287 /- 191 in group III. Plasma endothelin-l level was elevated significantly, and endothelin-1-like immunoreactivity was found in a variety ofpulmonary vascular tissue and was seen less with immunohistochemical evaluation in group II in bronchial tissue. Conclusions: These resultssuggest that endothelin-l is expressed as a result of ischemia-reperfusion injury and may worsen early graft function. TAK-044 is beneficial in protecting the graft from high pulmonary vascular resistance and pulmonary edema during the early posttransplantation stage.

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Documento generato il 03/04/20 alle ore 13:05:48