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Titolo:
ADULT HUMAN CARDIOMYOCYTES COEXPRESS VIMENTIN AND KI67 IN HEART-TRANSPLANT REJECTION AND IN DILATED CARDIOMYOPATHY
Autore:
BEHR TM; SPES CH; PONGRATZ DE; WEISS M; MEISER B; UBERFUHR P; THEISEN K; ANGERMANN CE;
Indirizzi:
UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN,KARDIOL ABT,DEPT CARDIOL,ZIEMSSENSTR 1 D-80336 MUNICH GERMANY
Titolo Testata:
The Journal of heart and lung transplantation
fascicolo: 8, volume: 17, anno: 1998,
pagine: 795 - 800
SICI:
1053-2498(1998)17:8<795:AHCCVA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERMEDIATE FILAMENT PROTEINS; MONOCLONAL-ANTIBODY KI-67; DESMIN FILAMENTS; NUCLEAR ANTIGEN; MYOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
T.M. Behr et al., "ADULT HUMAN CARDIOMYOCYTES COEXPRESS VIMENTIN AND KI67 IN HEART-TRANSPLANT REJECTION AND IN DILATED CARDIOMYOPATHY", The Journal of heart and lung transplantation, 17(8), 1998, pp. 795-800

Abstract

Background: The aim of this study was to investigate whether adult human cardiomyocytes may reexpress vimentin and whether this is linked to cellular activation. Methods: Myocardial samples of 81 heart transplant recipients (n = 183) and patients with dilated cardiomyopathy (n =10) were investigated by immunohistochemistry with the use of the marker molecule vimentin, the muscle-specific protein desmin, and Ki67, amarker for cell activation. Results: Vimentin protein expression in cardiomyocytes was found in 28 samples of transplant recipients and 5 myocardial samples of patients with dilated cardiomyopathy. Coexpression of vimentin and Ki67 was found in 52 of 340 vimentin-positive cardiomyocytes. Conclusions: We suggest that the vimentin/Ki67 coexpression indicates cell, activation processes as the result of different growthstimuli.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:03:27