Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MODULATION OF EOSINOPHILIC CHEMOTAXIS WITH AZELASTINE AND BUDESONIDE IN ALLERGIC PATIENTS
Autore:
VENTURA MT; GIULIANO G; DICORATO R; TURSI A;
Indirizzi:
UNIV BARI,DEPT INTERNAL MED IMMUNOL & INFECT DIS BARI ITALY
Titolo Testata:
Immunopharmacology and immunotoxicology
fascicolo: 3, volume: 20, anno: 1998,
pagine: 383 - 398
SICI:
0892-3973(1998)20:3<383:MOECWA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; BRONCHIAL-ASTHMA; HUMAN NEUTROPHIL; GUINEA-PIGS; GM-CSF; SPUTUM; CELLS; INHIBITION; MACROPHAGE; HYDROCHLORIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Ventura et al., "MODULATION OF EOSINOPHILIC CHEMOTAXIS WITH AZELASTINE AND BUDESONIDE IN ALLERGIC PATIENTS", Immunopharmacology and immunotoxicology, 20(3), 1998, pp. 383-398

Abstract

In this paper, the effect of azelastine hydrochloride, a potent inhibitor of leukotrienes (LTs) and H1 receptors for histamine, was assessed as regards modulation of in vitro eosinophilic chemotaxis. Tn this respect, chemotaxis of eosinophils (EOS), isolated from the peripheral blood of untreated allergic: subjects in the acute phase, was significantly diminished after in vitro treatment with azelastine ill comparison to values before treatment. When EOS were pre-incubated with serialdilutions of the drug, it was observed that azelastine inhibited chemotaxis in a dose-dependent fashion. Since azelastine acts in vitro as a regulator of the calcium pump, EOS were pre-incubated with differentconcentrations (0.6 and 3.0 mM) of Ca++. In these experimental conditions azelastine was able to reduce EOS chemotactic activity only in the presence of 0.6 mM Ca++, whereas with higher Ca++ concentrations (3.0 mM) the inhibitory effect of the drug was abrogated. On the other hand, particular attention was paid to inhaled budesonide, a non halogenated glucocorticosteroid derivative, structurally related to 16 alpha-hydroxy prednisolone, which represents a helpful for treatment mild tomoderate asthma. Data obtained after in vivo treatment with budesonide of a group of allergic patients demonstrated that EOS chemotactic activity was significantly reduced in these subjects. Conclusivesly our data show that 1) azelastine acts as a dose-dependent antagonist of chemotaxis; 2) it may exert this action by inhibiting Ca++ flow into cells; 3) inhaled budesonide may induce inhibition of bronchial inflammation by downregulating, EOS chemotactic capacity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:34:21