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Titolo:
PROFILE OF CEREBROSPINAL-FLUID AND SERUM CYTOKINES IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE-SCLEROSIS - A CORRELATION WITH CLINICAL ACTIVITY
Autore:
CARRIERI PB; PROVITERA V; DEROSA T; TARTAGLIA G; GORGA F; PERRELLA O;
Indirizzi:
UNIV NAPLES,DEPT NEUROL SCI,VIA S PANSINI 5 I-80131 NAPLES ITALY UNIV NAPLES 2,INST MICROBIOL NAPLES ITALY HOSP D COTUGNO NAPLES ITALY
Titolo Testata:
Immunopharmacology and immunotoxicology
fascicolo: 3, volume: 20, anno: 1998,
pagine: 373 - 382
SICI:
0892-3973(1998)20:3<373:POCASC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; NEUROLOGICAL DISORDERS; T-LYMPHOCYTES; TNF-ALPHA; ENCEPHALOMYELITIS; INTERLEUKIN-10; MARKERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P.B. Carrieri et al., "PROFILE OF CEREBROSPINAL-FLUID AND SERUM CYTOKINES IN PATIENTS WITH RELAPSING-REMITTING MULTIPLE-SCLEROSIS - A CORRELATION WITH CLINICAL ACTIVITY", Immunopharmacology and immunotoxicology, 20(3), 1998, pp. 373-382

Abstract

Levels of tumor necrosis factor (TNF)-alpha, granulocyte macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-10 and transforming growth factor (TGF)-beta in cerebrospinal fluid (CSF) and serum of 29 patients with multiple sclerosis (MS) of the relapsing-remitting type and of 20 controls with other non inflammatory neurological diseaseswere studied. Sixteen patients were in the active phase of disease and 13 in remission. In CSF, higher IL-10 and TGF-P concentrations were found in patients with a stable phase of MS, while in the active phasethere were elevated levels of TNF-a and GM-CSF. These results suggestthat a different cytokine pattern could be probably involved in the pathogenesis of relapsing-remitting MS.

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Documento generato il 29/02/20 alle ore 15:07:54