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Titolo:
SIV-ASSOCIATED NEPHROPATHY IN RHESUS MACAQUES INFECTED WITH LYMPHOCYTE-TROPIC SIV(MAC)239
Autore:
GATTONE VH; TIAN CQ; ZHUGE W; SAHNI M; NARAYAN O; STEPHENS EB;
Indirizzi:
UNIV KANSAS,MED CTR,MARION MERRELL DOW LAB VIRAL PATHOGENESIS,DEPT MICROBIOL MOL GENET & IMMUNOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,MARION MERRELL DOW LAB VIRAL PATHOGENESIS,DEPT MICROBIOL MOL GENET & IMMUNOL KANSAS CITY KS 66160 UNIV KANSAS,MED CTR,MARION MERRELL DOW LAB VIRAL PATHOGENESIS,DEPT ANAT & CELL BIOL KANSAS CITY KS 66160
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 13, volume: 14, anno: 1998,
pagine: 1163 - 1180
SICI:
0889-2229(1998)14:13<1163:SNIRMI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMIAN IMMUNODEFICIENCY VIRUS; HIV-ASSOCIATED NEPHROPATHY; SEGMENTAL GLOMERULOSCLEROSIS; ENZYMATIC AMPLIFICATION; PERSISTENT INFECTION; MACROPHAGE TROPISM; TRANSGENIC MICE; NERVOUS-SYSTEM; AIDS; MONKEYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
V.H. Gattone et al., "SIV-ASSOCIATED NEPHROPATHY IN RHESUS MACAQUES INFECTED WITH LYMPHOCYTE-TROPIC SIV(MAC)239", AIDS research and human retroviruses, 14(13), 1998, pp. 1163-1180

Abstract

We examined the renal pathology and viral genetic changes following inoculation of six rhesus macaques with lymphocyte-tropic SIV(mac)239, Portions of the renal cortex were sieved into glomerular and tubulointerstitial (TI) fractions and examined for SIVmac sequences by PCR and for p27 core antigen. SIVmac sequences were detected in renal tissue from five of six macaques (three of five glomerular and five of five TIfractions were positive for SIV by PCR), Glomerulosclerosis (segmental and global) was evident in two macaques that were positive for env sequences in the glomerular fractions. Diffuse mesangial hyperplasia and matrix expansion were present in all three animals with glomerular SIV, as was an increase in glomerular collagen I and collagen IV. Tubulointerstitial inflammation was evident in all virus-inoculated macaques, The TI infiltration of CD68(+) cells was most pronounced in the animals with SIVmac present in the glomerulus. All SIVmac-infected macaques exhibited increased glomerular deposition of IgM and to a lesser extent IgG, but no C3 or IgA was evident. Sequence analyses of the viralenv gene (gp120) isolated from the glomerular and TI fractions of a macaque that developed glomerulopathy revealed the presence of specificviral variants in glomerular and TI fractions. In addition, chimeric viruses constructed with glomerular but not tubulointerstitial gp120 sequences were converted to a macrophage-tropic phenotype, These results indicate that infection by lymphocyte-tropic SIV(mac)239 is primarily associated with immunoglobulin deposition in the glomerulus and suggests that when glomerulosclerosis develops there is selection of viralvariants that are macrophage tropic in nature.

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Documento generato il 30/11/20 alle ore 01:57:38