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Titolo:
BLOOD-FLOW AND CEREBRAL LATERALITY IN THE MESCALINE MODEL OF PSYCHOSIS
Autore:
HERMLE L; GOUZOULISMAYFRANK E; SPITZER M;
Indirizzi:
PSYCHIAT KLIN CHRISTOPHSBAD,FAURNDAUER STR 16 D-73035 GOPPINGEN GERMANY DEPT PSYCHIAT CHRISTOPHSBAD GOPPINGEN GERMANY RHEIN WESTFAL TH AACHEN,DEPT PSYCHIAT AACHEN GERMANY UNIV ULM,DEPT PSYCHIAT D-89069 ULM GERMANY
Titolo Testata:
Pharmacopsychiatry
, volume: 31, anno: 1998, supplemento:, 2
pagine: 85 - 91
SICI:
0176-3679(1998)31:<85:BACLIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE-METABOLISM; SCHIZOPHRENIC-PATIENTS; DISCONNECTION; ENTACTOGENS; AGENTS; MDE; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
L. Hermle et al., "BLOOD-FLOW AND CEREBRAL LATERALITY IN THE MESCALINE MODEL OF PSYCHOSIS", Pharmacopsychiatry, 31, 1998, pp. 85-91

Abstract

The psychological, neuropsychological, and neurometabolic effects of the hallucinogenic agent mescaline were investigated in 12 normal malevolunteers. Between 3 1/2 and 4 hours after drug intake, mescaline produced an acute psychotomimetic state, as measured by the BPRS and PDS-P. The APZ questionnaire revealed the specific effects of mescaline in the visual system. Neuropsychological effects were studied with a face/ non-face decision task with known right hemisphere advantage, in which mescaline induced a decrease in functioning of the right hemisphere. In functional brain imaging using SPECT, mescaline produced a ''hyperfrontal'' pattern with an emphasis on the right hemisphere, which was correlated with mescaline-induced psychotomimetic psychopathology. Our findings question the validity of the concept of hypofrontality asan explanation for a cute psychotic symptomatology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 01:14:44