Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IDENTIFICATION OF CERAMIDE TARGETS IN INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA SIGNALING IN MESANGIAL CELLS
Autore:
PFEILSCHIFTER J; HUWILER A;
Indirizzi:
UNIV FRANKFURT KLINIKUM,ZENTRUM PHARMAKOL,THEODOR STERN KAI 7 D-60590FRANKFURT GERMANY UNIV UTRECHT,CTR BIOMEMBRANES & LIPID ENZYMOL UTRECHT NETHERLANDS
Titolo Testata:
Kidney international
, volume: 54, anno: 1998, supplemento:, 67
pagine: 34 - 39
SICI:
0085-2538(1998)54:<34:IOCTII>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; N-TERMINAL KINASE; STRESS; RAF; ISOENZYMES; IMMUNOCHARACTERIZATION; TRANSDUCTION; STIMULATION; MECHANISMS; RESPONSES;
Keywords:
EXTRACELLULAR SIGNAL-REGULATED KINASE; PROTEIN KINASE C; SPHINGOMYELIN; MITOGEN-ACTIVATED PROTEIN KINASE; [I-125] IODINE-SPECIFIC RADIOACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J. Pfeilschifter e A. Huwiler, "IDENTIFICATION OF CERAMIDE TARGETS IN INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA SIGNALING IN MESANGIAL CELLS", Kidney international, 54, 1998, pp. 34-39

Abstract

An increasing number of cell-surface receptors have been shown to trigger sphingomyelin turnover and generation of the lipid signaling molecule ceramide. Ceramide plays a role in mediating cellular responses as diverse as inflammation, differentiation, gene expression, growth suppression, and apoptosis. A radioiodinated, photoaffinity-labeling analog of ceramide ([I-125]TID-ceramide) was used to identify downstream signaling targets of ceramide. Ceramide was found to bind specificallyto and activate protein kinase c-Raf, leading to subsequent activation of the extracellular signal-regulated kinase (ERK) module in mesangial cells. We found also that ceramide binds to and differentially modulates the activity of distinct protein kinase C isoenzymes. These dataare discussed in the context of interleukin 1 beta-induced inflammatory gene expression in mesangial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 05:11:47