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Titolo:
SEGMENTAL MUSCLE-FIBER LESIONS AFTER REPETITIVE ECCENTRIC CONTRACTIONS
Autore:
FRIDEN J; LIEBER RL;
Indirizzi:
GOTHENBURG UNIV,SAHLGRENS HOSP,DEPT HAND SURG S-41345 GOTHENBURG SWEDEN UNIV CALIF SAN DIEGO,DEPT ORTHOPAED SAN DIEGO CA 92103 UNIV CALIF SAN DIEGO,BIOMED SCI GRAD GRP SAN DIEGO CA 92103 VET ADM MED CTR SAN DIEGO CA 92161
Titolo Testata:
Cell and tissue research
fascicolo: 1, volume: 293, anno: 1998,
pagine: 165 - 171
SICI:
0302-766X(1998)293:1<165:SMLARE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; INTERMEDIATE FILAMENTS; TITIN FILAMENTS; EXERCISE; INJURY; DAMAGE; FIBRONECTIN; TRANSVERSE; PROTEINS; MEMBRANE;
Keywords:
MUSCLE INJURY; CYTOSKELETON; SARCOMERE ORGANIZATION; IMMUNOHISTOCHEMISTRY; ULTRASTRUCTURE; RABBIT (NEW ZEALAND WHITE);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J. Friden e R.L. Lieber, "SEGMENTAL MUSCLE-FIBER LESIONS AFTER REPETITIVE ECCENTRIC CONTRACTIONS", Cell and tissue research, 293(1), 1998, pp. 165-171

Abstract

Immunohistochemical and electron-microscopic techniques were used to analyze the extensor digitorum longus muscles of New Zealand White rabbits 1 h, I day, 3, 7, and 28 days after repetitive eccentric contractions. Loss of the cytoskeletal protein desmin was the earliest manifestation of injury. Apart from 1 h post-exercise, all desmin-negative fibers stained positively with antibody to plasma fibronectin, indicating loss of cellular integrity accompanying cytoskeletal disruption. Fiber sizes were significantly increased from 1-7 days after exercise. The large (hyaline) fibers found in histological sections after repetitive eccentric contractions resulted from segmental hypercontraction of the fiber. This phenomenon occurred proximally and distally to plasma membrane lesions of the muscle fiber and necrosis and manifested itself as very short sarcomere lengths. Thus, in serial sections, staining characteristics, sizes and shapes of one and the same fiber often varied dramatically. We conclude that the following sequence of events occurs: cytoskeletal disruptions, loss of myofibrillar registry, i.e., Z-disk streaming and A-band disorganization, and loss of cell integrity as manifested by intracellular plasma fibronectin stain, hypercontracted regions, and invasion of cells. When a fiber is disrupted, the remaining intact fibers apparently take up the tension put on the muscle and later fewer fibers are subjected to eccentric contractions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 02:29:26