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Titolo:
PLASTICITY OF CONGO RED STAINING DISPLAYED BY SUBPOPULATIONS OF NEURONS WITHIN THE RAT CENTRAL-NERVOUS-SYSTEM
Autore:
MIGUELHIDALGO JJ; ALVAREZ A; CACABELOS R;
Indirizzi:
EUROESPES BIOMED RES CTR,DEPT BASIC NEUROSCI,SANTA MARTA BABIO E-15166 LA CORUNA SPAIN
Titolo Testata:
Cell and tissue research
fascicolo: 1, volume: 293, anno: 1998,
pagine: 75 - 86
SICI:
0302-766X(1998)293:1<75:POCRSD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; CDP-CHOLINE; HIPPOCAMPAL-NEURONS; CEREBRAL-CORTEX; TIME-COURSE; BRAIN; DEGENERATION; MECHANISMS; AXOTOMY; INJURY;
Keywords:
HIPPOCAMPUS; RED NUCLEUS; CDP-CHOLINE; BETA-AMYLOID PRECURSOR PROTEIN; MAP2; RAT (SPRAGUE DAWLEY);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Miguelhidalgo et al., "PLASTICITY OF CONGO RED STAINING DISPLAYED BY SUBPOPULATIONS OF NEURONS WITHIN THE RAT CENTRAL-NERVOUS-SYSTEM", Cell and tissue research, 293(1), 1998, pp. 75-86

Abstract

We document the presence of subpopulations of neurons within the rat central nervous system that are labelled with a new Congo red stainingtechnique. These neurons (CR neurons) show shrunken somata, and smaller and darker nuclei than Congo red-negative cells (non-CR cells). With the Bielschowsky and the cresyl violet Nissl staining methods, two comparable subpopulations of cells can be distinguished by the same morphometrical criteria as those used for CR and non-CR cells. CR neuronsare located preferentially in some brain regions while in others theyare virtually absent. Their distribution and proportion varied greatly from animal to animal and after particular treatments. Injections ofwater that damaged the hippocampal dentate gyrus, cortical lesions oreye enucleation decreased the number of CR-cells in the CA1 subfield,reflected in a shift from the CR-staining subclass to the non-CR subclass. Treatment with 200 mg/kg of CDP-choline also significantly reduced the number of CR cells observed in CA1. In the red nucleus, CR neurons showed a characteristic distribution of beta-amyloid precursor protein (APP) immunoreactivity. The population of dendrites immunolabelled for microtubule-associated protein 2 was markedly decreased in the areas of the hippocampus with high numbers of CR cells Therefore, it isproposed that neurons labelled with the present Congo red technique might be in a reversible degenerative state or represent a particular physiological state in some areas of the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:11:15