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Titolo:
AGE-DEPENDENT LOCAL MODULATION OF HIPPOCAMPAL-EVOKED RESPONSES TO PERFORANT PATH STIMULATION
Autore:
LEVKOVITZ Y; SEGAL M;
Indirizzi:
WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL WEIZMANN INST SCI,DEPT NEUROBIOL IL-76100 REHOVOT ISRAEL
Titolo Testata:
Neurobiology of aging
fascicolo: 4, volume: 19, anno: 1998,
pagine: 317 - 324
SICI:
0197-4580(1998)19:4<317:ALMOHR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RAT DENTATE GYRUS; INHIBITORY INTERNEURONS; SYNAPTIC TRANSMISSION; CHOLINERGIC SYSTEM; 5-HT1A RECEPTORS; HILAR NEURONS; SEROTONIN; ACETYLCHOLINE; BEHAVIOR;
Keywords:
SEROTONIN; ACETYLCHOLINE; GABA; AGING; INTERNEURONS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
Y. Levkovitz e M. Segal, "AGE-DEPENDENT LOCAL MODULATION OF HIPPOCAMPAL-EVOKED RESPONSES TO PERFORANT PATH STIMULATION", Neurobiology of aging, 19(4), 1998, pp. 317-324

Abstract

Local modulation of hippocampal-evoked responses to perforant path stimulation was studied by leaking drugs from the recording pipette placed in the dentate gyrus of anesthetized young (3 months old), aging (17 months old) and old (28 months old) rats. In old rats, the excitatory postsynaptic potential (EPSP) slope was much reduced compared to young: and aging rats. The population spike (PS) size was similar in all age groups. Bicuculline caused a marked increase in PS size relative to population EPSP, and reversed the response to the second pulse in a paired-pulse paradigm from inhibition to facilitation. The effect of bicuculline was only slightly reduced in old rats. The 5-HT1a agonist 8-OH-DPAT potentiated PSs in the dentate gyrus, while not affecting paired-pulse inhibition. The effect of 8-OH-DPAT was slightly reduced in old rats. Carbachol, a cholinergic agonist, reversed paired-pulse inhibition into facilitation in the young brain, but not in aging and old rats. These results demonstrate that age affects differentially the action of biogenic amines on hippocampal reactivity to efferent stimulation. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:37:33