Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SYSTEMIC AND UTERINE BLOOD-FLOW DISTRIBUTION DURING PROLONGED INFUSION OF 17-BETA-ESTRADIOL
Autore:
MAGNESS RR; PHERNETTON TM; ZHENG J;
Indirizzi:
UNIV WISCONSIN,DEPT OBSTET & GYNECOL,PERINATAL RES LABS,7E MERITER HOSP PK,202 S PKST MADISON WI 53715
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 44, anno: 1998,
pagine: 731 - 743
SICI:
0363-6135(1998)44:3<731:SAUBDD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-INDUCED VASODILATION; HORMONE-REPLACEMENT THERAPY; NITRIC-OXIDE SYNTHESIS; NONREPRODUCTIVE TISSUES; POSTMENOPAUSAL WOMEN; OOPHORECTOMIZED EWES; CARDIAC-OUTPUT; SHEEP; ESTRADIOL-17-BETA; RESPONSES;
Keywords:
BLOOD PRESSURE; CARDIAC OUTPUT; VASCULAR RESISTANCE; HORMONE REPLACEMENT THERAPY; PREGNANCY; ESTROGEN; OVINE MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
R.R. Magness et al., "SYSTEMIC AND UTERINE BLOOD-FLOW DISTRIBUTION DURING PROLONGED INFUSION OF 17-BETA-ESTRADIOL", American journal of physiology. Heart and circulatory physiology, 44(3), 1998, pp. 731-743

Abstract

Prolonged 17 beta-estradiol (E(2)beta) infusion decreases mean arterial pressure (MAP) and systemic vascular resistance (SVR) while increasing heart rate (HR) and cardiac output (CO). It is unclear, however, which systemic vascular beds show increases in perfusion. The purpose of this study was to determine which reproductive and nonreproductive vascular beds exhibit alterations in vascular resistance and blood flowduring prolonged E(2)beta infusion. Nonpregnant, ovariectomized sheepreceived either vehicle (n = 6) or E(2)beta (5 mu g/kg iv bolus followed by 6 mu g/kg over 24 h for 10 days; n = 9), and blood flow distribution was evaluated using radiolabeled microspheres at control and 120min and 3, 6, 8, and 10 days of infusion. During E(2)beta infusion MAP (87 +/- 5 mmHg; mean +/- SE) decreased 3-9% and HR (83 +/- 5 beats/min) increased 4-31%. The combined baseline (control) perfusion to the uterus, broad ligament, oviducts, cenix, vagina, and mammary gland (reproductive blood flows) was 49 +/- 9 ml/min; at 120 min, E(2)beta increased flow (P < 0.001) to 605 +/- 74 ml/min (1,263%) and it remained elevated, but at a reduced rate, on day 3 (218 +/- 44 ml/min; 399%), day 6 (144 +/- 23; 217%), day 8 (181 +/- 19; 321%), and day 10 (204 +/- 48; 454%), accounting for only 3-17% of the E(2)beta-induced increase in CO. During this E(2)beta treatment, there also were significant decreases in vascular resistances leading to increases (P < 0.05) in blood flows to several nonreproductive (systemic) vascular beds including skin (32-113%), coronary (32-190%), skeletal muscle (25-133%), brain (21-292%), bladder (128-524%), spleen (87-180%), and pancreas (35-137%)vascular beds. Responses of these combined nonreproductive blood flows represent the major percentage (21-67%) of the E(2)beta-induced increase in CO. Vehicle infusion was without effect. We conclude that prolonged E(2)beta infusion increases reproductive and nonreproductive tissue blood flows. The latter appears to principally be responsible for the observed rise in CO and decrease in SVR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:42:22