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Titolo:
GLUCAGON-LIKE PEPTIDE-1 INCREASES THE PERIOD OF POSTPRANDIAL SATIETY AND SLOWS GASTRIC-EMPTYING IN OBESE MEN
Autore:
NASLUND E; GUTNIAK M; SKOGAR S; ROSSNER S; HELLSTROM PM;
Indirizzi:
KAROLINSKA INST,DANDERYD HOSP,DEPT SURG SE-18288 STOCKHOLM SWEDEN MULTIDISCIPLINARY PAIN CTR KRONAN STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT GASTROENTEROL & HEPATOL S-10401 STOCKHOLM SWEDEN HUDDINGE UNIV HOSP,OBES UNIT STOCKHOLM SWEDEN
Titolo Testata:
The American journal of clinical nutrition
fascicolo: 3, volume: 68, anno: 1998,
pagine: 525 - 530
SICI:
0002-9165(1998)68:3<525:GPITPO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-INTAKE; RAT-BRAIN; BINDING-SITES; IDENTIFICATION; ENTEROGLUCAGON; GLICENTIN; SECRETION; SEQUENCE;
Keywords:
GLUCAGON-LIKE PEPTIDE 1; GLP-1; GLUCOSE; INSULIN; GLUCAGON; C-PEPTIDE; SATIETY; GASTRIC EMPTYING; VISUAL ANALOG SCALES; FOOD INTAKE; OBESITY; HUMANS; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
E. Naslund et al., "GLUCAGON-LIKE PEPTIDE-1 INCREASES THE PERIOD OF POSTPRANDIAL SATIETY AND SLOWS GASTRIC-EMPTYING IN OBESE MEN", The American journal of clinical nutrition, 68(3), 1998, pp. 525-530

Abstract

The gut peptide glucagon-like peptide 1(7-36) amide (GLP-1) is released into the circulation after food intake. GLP-1 has been shown to have an incretin effect and inhibits gastrointestinal motility in humans. In rats, intracerebral administration of GLP-1 results in reduced food intake. Obese humans have been found to have an attenuated plasma GLP-1 response to a mixed meal. To approximate the physiologic state, GLP-1 or saline was administered intravenously and randomly at the beginning of a test meal served on a universal eating monitor to 6 obese subjects to test our hypothesis that GLP-1 influences termination of food intake (and thus food intake during a meal) and feelings of satiety in humans. As a marker for gastric emptying, 1.5 g acetaminophen was given at the start of the meal. Blood samples for analysis of acetaminophen, insulin, glucose, glucagon, and C-peptide were obtained. Hunger,fullness, and food choice were assessed with visual analogue scales and food-choice questionnaires. GLP-1 infusion resulted in a prolonged period of reduced feelings of hunger, desire to eat, and prospective consumption after the meal. The rate of gastric emptying was slower during infusion of GLP-1. Postprandial blood glucose concentrations were reduced during the GLP-1 infusion, but the amount of energy consumed, eating rate, and plasma concentrations of insulin, glucagon, and C-peptide were unchanged. GLP-1 given exogenously at the start of a meal did not seem to affect meal termination or the amount of food eaten. However, postprandial feelings of hunger decreased, suggesting that exogenous GLP-1 may influence feelings of hunger and satiety in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:58:23