Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MARKED REDUCTION IN BILE-ACID SYNTHESIS IN CHOLESTEROL 7-ALPHA-HYDROXYLASE-DEFICIENT MICE DOES NOT LEAD TO DIMINISHED TISSUE CHOLESTEROL TURNOVER OR TO HYPERCHOLESTEROLEMIA
Autore:
SCHWARZ M; RUSSELL DW; DIETSCHY JM; TURLEY SD;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT MOL GENET DALLAS TX 75235
Titolo Testata:
Journal of lipid research
fascicolo: 9, volume: 39, anno: 1998,
pagine: 1833 - 1843
SICI:
0022-2275(1998)39:9<1833:MRIBSI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; DIETARY-CHOLESTEROL; OXYSTEROL 7-ALPHA-HYDROXYLASE; CYNOMOLGUS MONKEY; LOWERING ACTION; ABSORPTION; LIVER; HAMSTER; PLASMA; STEROL;
Keywords:
CHOLESTEROL 7-ALPHA-HYDROXYLASE; CHOLESTEROL ABSORPTION; CHOLESTEROL SYNTHESIS; BILE ACID POOL SIZE; LIVER; SMALL INTESTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
M. Schwarz et al., "MARKED REDUCTION IN BILE-ACID SYNTHESIS IN CHOLESTEROL 7-ALPHA-HYDROXYLASE-DEFICIENT MICE DOES NOT LEAD TO DIMINISHED TISSUE CHOLESTEROL TURNOVER OR TO HYPERCHOLESTEROLEMIA", Journal of lipid research, 39(9), 1998, pp. 1833-1843

Abstract

These studies used mice that were deficient in cholesterol 7 alpha-hydroxylase to determine the effects of reduced bile acid synthesis on cholesterol homeostasis. In mice lacking this enzyme, bile acid synthesis was reduced from 8.3 to 3.4 mu mol/day per 100 g body weight, the intestinal bile acid pool was decreased from 62.5 to 13.2 mu mol/100 g bw, and the proportion of hyodeoxycholate, relative to cholate, in this pool was significantly increased, Associated with these changes, intestinal cholesterol absorption decreased from 37% to <1% while triacylglycerol absorption and animal weight gain remained essentially unaffected. The very low rate of cholesterol absorption could be corrected by feeding the mutant mice cholate, but not hyodeoxycholate, The reduction in sterol uptake across the intestine was associated with a 2-foldincrease in cholesterol synthesis in the small bowel and liver and anincrease in fecal neutral sterol excretion from 15.2 to 35.7 mu mol/day per 100 g bu: The size of the cholesterol pools in the plasma, various organs and whole animal remained constant. Thus, under circumstances where the excretion of sterol as bile acids was markedly reduced, total cholesterol turnover actually increased from 164 to 239 mg/day per kg bw. This study demonstrates the complex interactions between bileacid and cholesterol metabolism and the dramatic effects of eliminating a single gene product; however, even though a major catabolic pathway was deleted, cholesterol balance across the animal was maintained.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:03:11