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Titolo:
FUNCTIONAL-CHARACTERIZATION OF ORCTL2 - AN ORGANIC CATION TRANSPORTEREXPRESSED IN THE RENAL PROXIMAL TUBULES
Autore:
REECE M; PRAWITT D; LANDERS J; KAST C; GROS P; HOUSMAN D; ZABEL BU; PELLETIER J;
Indirizzi:
MCGILL UNIV,DEPT BIOCHEM,RM 902,3655 DRUMMOND ST MONTREAL PQ H3G 1Y6 CANADA MCGILL UNIV,DEPT BIOCHEM MONTREAL PQ H3G 1Y6 CANADA UNIV MAINZ,DEPT PEDIAT D-55101 MAINZ GERMANY MIT,CTR CANC RES CAMBRIDGE MA 02139 MCGILL UNIV,DEPT ONCOL MONTREAL PQ H3G 1Y6 CANADA
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 433, anno: 1998,
pagine: 245 - 250
SICI:
0014-5793(1998)433:3<245:FOO-AO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BECKWITH-WIEDEMANN SYNDROME; ESCHERICHIA-COLI; RESISTANCE; GENE; LOCALIZATION; MOUSE;
Keywords:
BECKWITH-WIEDEMANN SYNDROME; ORGANIC CATION TRANSPORTER; TETRACYCLINE/H+ ANTIPORTER; ORGANIC CATION TRANSPORTER-LIKE 2; 11P15.5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M. Reece et al., "FUNCTIONAL-CHARACTERIZATION OF ORCTL2 - AN ORGANIC CATION TRANSPORTEREXPRESSED IN THE RENAL PROXIMAL TUBULES", FEBS letters, 433(3), 1998, pp. 245-250

Abstract

Chromosome 11p15.5 harbors a gene or genes involved in Beckwith-Wiedemann syndrome that confer(s) susceptibility to Wilms' tumor, rhabdomyosarcoma, and hepatoblastoma, We have previously identified a transcript at 11p15.5 which encodes a putative membrane transport protein, designated organic cation transporter-like 2 (ORCTL2), that shares homology with tetracycline resistance proteins and bacterial multidrug resistance proteins. In this report, we have investigated the transport properties of ORCTL2 and show that this protein can confer resistance to chloroquine and quinidine when overexpressed in bacteria, Immunohistochemistry analyses performed with anti-ORCTL2 polyclonal antibodies on human renal sections indicate that ORCTL2 is localized on the apical membrane surface of the proximal tubules, These results suggest that ORCTL2 may play a role in the transport of chloroquine and quinidine related compounds in the kidney. (C) 1998 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 05:46:51