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Titolo:
ENZYMATIC REPAIR OF OXIDATIVE DAMAGE TO HUMAN APOLIPOPROTEIN-A-I
Autore:
SIGALOV AB; STERN LJ;
Indirizzi:
AMW CO LTD,BIOMED DEPT,22-1-11 TARUSSKAYA ST MOSCOW 117588 RUSSIA MIT,DEPT CHEM CAMBRIDGE MA 02139
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 433, anno: 1998,
pagine: 196 - 200
SICI:
0014-5793(1998)433:3<196:EROODT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; METHIONINE SULFOXIDE; LIPID-FREE; CONFORMATION; LOCALIZATION; REDUCTION;
Keywords:
APOLIPOPROTEIN A-I; METHIONINE OXIDATION; ENZYMATIC REDUCTION; PEPTIDE METHIONINE SULFOXIDE REDUCTASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Sigalov e L.J. Stern, "ENZYMATIC REPAIR OF OXIDATIVE DAMAGE TO HUMAN APOLIPOPROTEIN-A-I", FEBS letters, 433(3), 1998, pp. 196-200

Abstract

Oxidative damage to apolipoprotein A-I that occurs in vivo commonly involves methionine oxidation, and is accompanied by alterations in structure, lipid association, and cholesterol efflux function. We have used the enzyme peptide methionine sulfoxide reductase (PMSR) to reversethis damage, and shown by a variety of criteria that enzyme treatmentrestores the primary, secondary, and tertiary structure and lipid association characteristic of the native unoxidized protein, lipid-associated as well as lipid-free apolipoprotein A-I reacts with PMSR, suggesting that enzymatic reduction of oxidized apolipoprotein A-I in high density lipoproteins can result in restoration of biological activity and the ability to promote cholesterol efflux from cells. (C) 1998 Federation of European Biochemical Societies.

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Documento generato il 11/07/20 alle ore 20:20:37