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Titolo:
PROPRANOLOL ATTENUATES HALOPERIDOL-INDUCED FOS EXPRESSION IN DISCRETEREGIONS OF RAT-BRAIN - POSSIBLE BRAIN-REGIONS RESPONSIBLE FOR AKATHISIA
Autore:
OHASHI K; HAMAMURA T; LEE Y; FUJIWARA Y; KURODA S;
Indirizzi:
OKAYAMA UNIV,SCH MED,DEPT NEUROPSYCHIAT,2-5-1 SHIKATA CHO OKAYAMA 700JAPAN OKAYAMA UNIV,SCH MED,DEPT NEUROPSYCHIAT OKAYAMA 700 JAPAN TAKAOKA HOSP HIMEJI HYOGO 670 JAPAN
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 802, anno: 1998,
pagine: 134 - 140
SICI:
0006-8993(1998)802:1-2<134:PAHFEI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; NEUROLEPTIC-INDUCED AKATHISIA; IMMEDIATE-EARLY GENES; C-FOS; NERVOUS-SYSTEM; FOREBRAIN; RECEPTORS; DOPAMINE; RELEASE; CLOZAPINE;
Keywords:
AKATHISIA; FOS; NEUROLEPTICS; BETA-ADRENOCEPTOR ANTAGONIST; PROPRANOLOL; EXTRA-PYRAMIDAL SIDE EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
K. Ohashi et al., "PROPRANOLOL ATTENUATES HALOPERIDOL-INDUCED FOS EXPRESSION IN DISCRETEREGIONS OF RAT-BRAIN - POSSIBLE BRAIN-REGIONS RESPONSIBLE FOR AKATHISIA", Brain research, 802(1-2), 1998, pp. 134-140

Abstract

Neuroleptics induce several extra-pyramidal side effects, such as akathisia, acute dystonia and parkinsonism.,Although recently developed atypical neuroleptics ameliorate some of these side effects, akathisia remains a common and severely distressing adverse reaction. Several drugs are reported to be of clinical use for the pharmacological treatment of akathisia. In particular, the P-adrenoceptor blocker, propranolol, has been widely used for the treatment of akathisia, but it does not ameliorate other extra-pyramidal side effects. To identify the neural substrates of akathisia, we investigated the effects of propranolol on haloperidol-induced Fos expression in rat brain. Haloperidol (1 mg/kg) induced Fos-positive nuclei in several regions of the brain, including the cingulate cortex area 3, piriform cortex, nucleus accumbens, caudate-putamen, ventral lateral septum and parietal cortex. Pretreatment with propranolol (5 mg/kg) reduced the number of Fos-positive nuclei in the cingulate cortex area 3, the piriform cortex and area 1 of the parietal cortex. Injection of vehicle by itself tended to increase Fos expression in the cingulate cortex area 3 and the piriform cortex. Considering the functions of these brain regions, we speculate that the most plausible neural framework for haloperidol-induced akathisia involves area I of the parietal cortex, but possible roles for the cingulate cortex area 3 and the piriform cortex cannot be ruled out. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:24:53