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Titolo:
AN EFFICIENT RADIOSYNTHESIS OF F-18! FLUOROMISONIDAZOLE
Autore:
LIM JL; BERRIDGE MS;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT RADIOL,2074 ABINGTON RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT CHEM CLEVELAND OH 44106 UNIV HOSP CLEVELAND CLEVELAND OH 44106
Titolo Testata:
Applied radiation and isotopes
fascicolo: 8, volume: 44, anno: 1993,
pagine: 1085 - 1091
SICI:
0969-8043(1993)44:8<1085:AEROF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOLABELED FLUOROMISONIDAZOLE; NUCLEOPHILIC-SUBSTITUTION; CYCLIC SULFATES; HYPOXIA; MISONIDAZOLE; BINDING; MARKERS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Lim e M.S. Berridge, "AN EFFICIENT RADIOSYNTHESIS OF F-18! FLUOROMISONIDAZOLE", Applied radiation and isotopes, 44(8), 1993, pp. 1085-1091

Abstract

An efficient preparation of the hypoxic cell tracer -18!3-fluoro-1-(2'-nitro-1'-imidazolyl)-2-propanol (F-18!fluoromisonidazole) is reported. This radiopharmaceutical is of interest to probe hypoxic tissue ininfarcts and tumors. One-step radiolabeling and rapid protection group removal provided 55-80% yield in 50 min. The process is similar to common fluorine labeling procedures, simplifying the procedure for mostlaboratories, and offers an improvement over more difficult previous methods. The labeling precursor was prepared in five steps from readily available materials in a straightforward reaction scheme.

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Documento generato il 19/09/20 alle ore 14:22:11