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Titolo:
SYNTHESIS OF AMPHIPHILIC PHOSPHATE-CARBONATE COPOLYMERS AND DRUG-RELEASE PROPERTY OF THEIR MICROSPHERES
Autore:
KE TY; ZHUO RX;
Indirizzi:
WUHAN UNIV,MINIST EDUC,LAB BIOMED POLYMER MAT,COLL CHEM WUHAN 430072 PEOPLES R CHINA WUHAN UNIV,MINIST EDUC,LAB BIOMED POLYMER MAT,COLL CHEM WUHAN 430072 PEOPLES R CHINA
Titolo Testata:
Gaodeng xuexiao huaxue xuebao
fascicolo: 8, volume: 19, anno: 1998,
pagine: 1335 - 1338
SICI:
0251-0790(1998)19:8<1335:SOAPCA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
CHI
Keywords:
AMPHIPHILIC PHOSPHATE-CARBONATE COPOLYMER; MICROSPHERE; IN VITRO DEGRADATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
T.Y. Ke e R.X. Zhuo, "SYNTHESIS OF AMPHIPHILIC PHOSPHATE-CARBONATE COPOLYMERS AND DRUG-RELEASE PROPERTY OF THEIR MICROSPHERES", Gaodeng xuexiao huaxue xuebao, 19(8), 1998, pp. 1335-1338

Abstract

Four amphiphilic phosphate-carbonate copolymers were synthesized by polycondensation of bisphenol A, phosgene and 2-bromoethyl phosphorodichloridate, and then quaternized with trimethylamine, The copolymers obtained were characterized by IR, H-1 NMR and elemental analysis, Average molecular weight ((M) over bar(n)) and water contact angle were measured, The in vitro degradation of copolymers was studied in pH 7.4 phosphate buffer solution at 37 degrees C, Microspheres of these coploymer were prepared, their morphology, size and in vitro drug release of 5-Fu were also investigated.

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Documento generato il 10/07/20 alle ore 15:55:43