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Titolo:
PARAMAGNETIC METAL-CHELATES OF DTPA-DIPYRIDOXOL AND EDTA-DIPYRIDOXOL ESTER DERIVATIVES AND THEIR NMR T-1 RELAXIVITIES IN WATER
Autore:
WEI JF; ZHUO RX;
Indirizzi:
WUHAN UNIV,DEPT CHEM WUHAN 430072 PEOPLES R CHINA
Titolo Testata:
Gaodeng xuexiao huaxue xuebao
fascicolo: 8, volume: 19, anno: 1998,
pagine: 1242 - 1246
SICI:
0251-0790(1998)19:8<1242:PMODAE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
CHI
Soggetto:
PRECLINICAL EVALUATION; CONTRAST AGENT; HEPATOBILIARY; LIVER; MRI;
Keywords:
MAGNETIC RESONANCE IMAGING CONTRAST AGENT; GADOLINIUM COMPLEX; PYRIDOXOL; AMINO-CARBOXY CHELATING AGENT; RELAXIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Wei e R.X. Zhuo, "PARAMAGNETIC METAL-CHELATES OF DTPA-DIPYRIDOXOL AND EDTA-DIPYRIDOXOL ESTER DERIVATIVES AND THEIR NMR T-1 RELAXIVITIES IN WATER", Gaodeng xuexiao huaxue xuebao, 19(8), 1998, pp. 1242-1246

Abstract

Several novel ligands of DTPA- and EDTA-dipyridoxolester derivatives have been synthesized by reaction of DTPA-dianhydride and EDTA-dianhydride with pyridoxol (vitamin Bg) in dry DMF. Their complexes of gadoliniun, manganese and iron were prepared and the measurements of T-1 relaxivities in solution of water in vitro were performed with the gadolinium and the manganese complexes. The results show that all of the complexes are highly water soluble and very slightly light and air sensitive both in solid state and in solution, The T-1 relaxivities of the complexes, for example, gadolinium-DTPA-dipyridoxolester, GdDTPA-BPN, and manganese-EDTA-dipyridoxolester, MnEDTA-BPN, were determined to be 5. 5 and 3. 1 L . mmol(-1) . s(-1), respectively. These can be compared to the values of the corresponding complexes of their parent ligands, GdDTPA(2-) and MnEDTA(2-), indicating the complexes are potentially useful contrast agents for magnetic resonance imaging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:52:48