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Titolo: NO SELF-INJURIOUS-BEHAVIOR WAS FOUND IN HPRT-DEFICIENT MICE TREATED WITH 9-ETHYLADENINE
Autore: EDAMURA K; SASAI H;
- Indirizzi:
- JAPAN TOBACCO INC,LIFE SCI RES LAB,AOBA KU,6-2 UMEGAOKA YOKOHAMA KANAGAWA 227 JAPAN
- Titolo Testata:
- Pharmacology, biochemistry and behavior
fascicolo: 2,
volume: 61,
anno: 1998,
pagine: 175 - 179
- SICI:
- 0091-3057(1998)61:2<175:NSWFIH>2.0.ZU;2-U
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- LESCH-NYHAN SYNDROME; DOPAMINE DEFICIENCY; MOUSE MODEL; DISEASE; AMPHETAMINE;
- Keywords:
- 9-ETHYLADENINE; APRT; HPRT-DEFICIENT MOUSE; SELF-INJURIOUS BEHAVIOR; LESCH-NYHAN SYNDROME;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 18
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- K. Edamura e H. Sasai, "NO SELF-INJURIOUS-BEHAVIOR WAS FOUND IN HPRT-DEFICIENT MICE TREATED WITH 9-ETHYLADENINE", Pharmacology, biochemistry and behavior, 61(2), 1998, pp. 175-179
Abstract
It has been reported that 9-ethyladenine (9-EA) is an efficient inhibitor of APRT (adenine phosphoribosyltransferase) and that its administration causes self-injurious behavior (Le-sch-Nyhan Syndrome-like symptoms) in HPRT (hypoxanthine-guanine phosphoribosyltransferase)-deficient mice. In contrast, we found neither any self-injurious behavior (SIB), such as visible injury or hair loss, nor any apparent decrease in APRT activity in HPRT-defecient mice treated with 9-EA. We also found that 9-EA has little irreversible or competitive inhibitory effect on APRT in vitro, even at a concentration of 10(-2) M. In light of the negative finding of SIE in APRT/HPRT double-deficient mice, it seems unlikely that SIE in HPRT-deficient mice is caused by lowered APRT activity. It is concluded that 9-EA is not a sufficient APRT inhibitor and cannot be used in experiments that mimic lowered APRT status in an animal model. (C) 1998 Elsevier Science Inc.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 00:14:00