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Titolo:
NO SELF-INJURIOUS-BEHAVIOR WAS FOUND IN HPRT-DEFICIENT MICE TREATED WITH 9-ETHYLADENINE
Autore:
EDAMURA K; SASAI H;
Indirizzi:
JAPAN TOBACCO INC,LIFE SCI RES LAB,AOBA KU,6-2 UMEGAOKA YOKOHAMA KANAGAWA 227 JAPAN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 61, anno: 1998,
pagine: 175 - 179
SICI:
0091-3057(1998)61:2<175:NSWFIH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
LESCH-NYHAN SYNDROME; DOPAMINE DEFICIENCY; MOUSE MODEL; DISEASE; AMPHETAMINE;
Keywords:
9-ETHYLADENINE; APRT; HPRT-DEFICIENT MOUSE; SELF-INJURIOUS BEHAVIOR; LESCH-NYHAN SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
K. Edamura e H. Sasai, "NO SELF-INJURIOUS-BEHAVIOR WAS FOUND IN HPRT-DEFICIENT MICE TREATED WITH 9-ETHYLADENINE", Pharmacology, biochemistry and behavior, 61(2), 1998, pp. 175-179

Abstract

It has been reported that 9-ethyladenine (9-EA) is an efficient inhibitor of APRT (adenine phosphoribosyltransferase) and that its administration causes self-injurious behavior (Le-sch-Nyhan Syndrome-like symptoms) in HPRT (hypoxanthine-guanine phosphoribosyltransferase)-deficient mice. In contrast, we found neither any self-injurious behavior (SIB), such as visible injury or hair loss, nor any apparent decrease in APRT activity in HPRT-defecient mice treated with 9-EA. We also found that 9-EA has little irreversible or competitive inhibitory effect on APRT in vitro, even at a concentration of 10(-2) M. In light of the negative finding of SIE in APRT/HPRT double-deficient mice, it seems unlikely that SIE in HPRT-deficient mice is caused by lowered APRT activity. It is concluded that 9-EA is not a sufficient APRT inhibitor and cannot be used in experiments that mimic lowered APRT status in an animal model. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:55:46