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Titolo:
BEHAVIORAL SATIETY SEQUENCE (BSS) FOR THE DIAGNOSIS OF DRUG-ACTION ONFOOD-INTAKE
Autore:
HALFORD JCG; WANNINAYAKE SCD; BLUNDELL JE;
Indirizzi:
UNIV LEEDS,DEPT PSYCHOL,BIOPSYCHOL GRP LEEDS LS2 9JT W YORKSHIRE ENGLAND UNIV LEEDS,DEPT PSYCHOL,BIOPSYCHOL GRP LEEDS LS2 9JT W YORKSHIRE ENGLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 61, anno: 1998,
pagine: 159 - 168
SICI:
0091-3057(1998)61:2<159:BSS(FT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR AGONIST; FEEDING-BEHAVIOR; MICROSTRUCTURAL ANALYSIS; RAT; SEROTONIN; 5-HT1B; TIME; FENFLURAMINE; FLUOXETINE; RU-24969;
Keywords:
BEHAVIORAL SATIETY SEQUENCE; FOOD INTAKE; LOCOMOTION; RESTING; SEROTONIN (5-HT); DOPAMINE (DA); CONTINUOUS OBSERVATION; OBESITY DRUGS; D-FENFLURAMINE; SIBUTRAMINE; FLUOXETINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
J.C.G. Halford et al., "BEHAVIORAL SATIETY SEQUENCE (BSS) FOR THE DIAGNOSIS OF DRUG-ACTION ONFOOD-INTAKE", Pharmacology, biochemistry and behavior, 61(2), 1998, pp. 159-168

Abstract

The Behavioral Satiety Sequence (BSS) is the name given to the orderly transitions of eating, activity grooming and resting measured duringthe postingestive period. Because the BSS is considered to reflect the operations of natural physiological processes underlying satiety, the sequence can be used to discriminate between different drugs land other manipulations) that reduce food intake via these natural physiological mechanisms or those that do so by interference. The BSS is only produced by the presence of a caloric load in the gut, and the preabsorptive satiety factors (such as CCK) the caloric load triggers. The BSSis most accurately defined by continuous observation rather than timeor event sampling techniques [Partial Time Sampling (PTS) or Momentary Time Sampling (MTS)]. Continuous observation also allows the true duration and true frequency of each behavior to be analyzed. Continuous observation can be used to determine if the profiles associated with the reduction in food intake is caused by nausea, sedation, hyperactivity, or altered palatability of food. At the present time is it possible to identify a number of drugs whose suppression of food intake is associated with the disruption or preservation of the BSS. Drugs that increase synaptic 5-HT activity such d-fenfluramine, fluoxetine, and sibutramine all preserve the BSS and advance the onset of resting. The 5-HT1b/2c agonists mCPP and TFMPP and the 5-HT1b agonist CP-94,253 produce similar effects. However, the 5-HT2 agonist DOI and the 5-HT1a/1b agonist RU-24969 disrupt the BSS by inducing hyperactivity as does amphetamine. The 5-HT2 agonist MK-212 disrupts the BSS by inducing sedation. Selective dopamine agonists, at low doses, such as SKF-38393 (DA(1)) and LY-171555 (DA(2)) also preserve the BSS. However, detailed behavioral analysis of the effects of many recently discovered putative satiety factors remains to be carried out. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 07:04:07