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Titolo:
THE EFFECTS OF COCAINE, AMPHETAMINE, AND THE DOPAMINE D-1 RECEPTOR AGONIST SKF-38393 ON FEAR EXTINCTION AS MEASURED WITH POTENTIATED STARTLE - IMPLICATIONS FOR PSYCHOMOTOR STIMULANT PSYCHOSIS
Autore:
BOROWSKI TB; KOKKINIDIS L;
Indirizzi:
UNIV CANTERBURY,DEPT PSYCHOL,PRIVATE BAG 4800 CHRISTCHURCH NEW ZEALAND UNIV SASKATCHEWAN,DEPT PSYCHOL SASKATOON SK S7N 0W0 CANADA
Titolo Testata:
Behavioral neuroscience
fascicolo: 4, volume: 112, anno: 1998,
pagine: 952 - 965
SICI:
0735-7044(1998)112:4<952:TEOCAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; ACTH-INDUCED RECOVERY; ACOUSTIC STARTLE; RAT-BRAIN; INTRAVENOUS COCAINE; CONDITIONED REINFORCEMENT; AVOIDANCE-RESPONSE; INDUCED PARANOIA; SENSITIZATION; STRESS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
121
Recensione:
Indirizzi per estratti:
Citazione:
T.B. Borowski e L. Kokkinidis, "THE EFFECTS OF COCAINE, AMPHETAMINE, AND THE DOPAMINE D-1 RECEPTOR AGONIST SKF-38393 ON FEAR EXTINCTION AS MEASURED WITH POTENTIATED STARTLE - IMPLICATIONS FOR PSYCHOMOTOR STIMULANT PSYCHOSIS", Behavioral neuroscience, 112(4), 1998, pp. 952-965

Abstract

Using Pavlovian conditioned increases in the amplitude of the acoustic startle reflex as a behavioral indicator of fear motivation, the authors previously showed a resistance to extinction after repeated associations of cocaine with the fear-evoking conditioned stimulus (CS). InExperiment 1, acute administration of cocaine, amphetamine, and the dopamine (DA) D-1 receptor agonist SKF 38393 produced a similar fear enhancement. In Experiment 2, a noncontingent injection of cocaine and SKF 38393 provoked a CS potentiation of acoustic startle in fear-extinguished laboratory rats. Potential behavioral, neurochemical, and neuroendocrine explanations for the effects of psychomotor stimulants on conditional fear were discussed. It was suggested that DA agonist drugs increase fear expression possibly by activating mesoamygdaloid associative neurocircuitry involved in excitatory conditioned fear reactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:45:57