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Titolo:
RELEASE OF NEUROTRANSMITTERS IN THE LOCUS-COERULEUS
Autore:
SINGEWALD N; PHILIPPU A;
Indirizzi:
UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN PHARMACOL,WOODSTOCK RD OXFORD OX2 6HE ENGLAND INNSBRUCK UNIV,DEPT PHARMACOL & TOXICOL A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
Progress in neurobiology
fascicolo: 2, volume: 56, anno: 1998,
pagine: 237 - 267
SICI:
0301-0082(1998)56:2<237:RONITL>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; EXCITATORY AMINO-ACIDS; IN-VIVO MICRODIALYSIS; NITRIC-OXIDE SYNTHASE; DIFFERENTIAL PULSE VOLTAMMETRY; TYROSINE-HYDROXYLASE ACTIVITY; BRAIN NORADRENERGIC NEURONS; PHASEOLUS-VULGARIS-LEUKOAGGLUTININ; NALOXONE-PRECIPITATED WITHDRAWAL; RECEPTOR-MEDIATED INHIBITION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
327
Recensione:
Indirizzi per estratti:
Citazione:
N. Singewald e A. Philippu, "RELEASE OF NEUROTRANSMITTERS IN THE LOCUS-COERULEUS", Progress in neurobiology, 56(2), 1998, pp. 237-267

Abstract

In the past 15 years the release of neurotransmitters and their metabolites in the locus coeruleus (LC) has been studied by using three approaches: microdialysis; push-pull superfusion; and voltammetry. These sophisticated techniques, which render it possible to follow the time course and magnitude of neurochemical changes in anaesthetized and conscious animals, have permitted great strides towards understanding neurotransmission in the LC. It appears that noradrenaline, known to be released in distant terminal fields, is also released in the somatodendritic area of LC neurons in response to drugs and physiological stimuli. Furthermore, determination of in vivo release enables the identification of functionally important neurotransmitter systems involved in relaying and integrating information reaching the LC via afferent neurons. As outlined in this review, the release rates of glutamate, aspartate, gamma-aminobutyric acid. glycine, 5-hydroxytryptamine and catecholamines, are modified in particular by arousing and stressful stimuli.pain, changes in cardiovascular homeostasis, as well as during opioidwithdrawal or the sleep-wake-cycle. Profound interactions also occur between some of the neurotransmitters released during these situations. It appears that individual stimuli produce distinct neurochemical changes which contribute to the regulation of neuronal LC activity. Stimuli that activate LC neurons, such as pain, fall of blood pressure, noise, opiate withdrawal, do not produce a uniform response but modality-specific release patterns of excitatory and inhibitory neurotransmitters within the LC. From these studies and from existing neuroanatomical and electrophysiological data our knowledge of how neurotransmitterswork in concert to regulate the functional state of LC noradrenergic perikarya in physiological and pathophysiological conditions is just emerging. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:40:26