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Titolo:
CHRONIC ALCOHOL INTAKE REDUCES RETINOIC ACID CONCENTRATION AND ENHANCES AP-1 (C-JUN AND C-FOS) EXPRESSION IN RAT-LIVER
Autore:
WANG XD; LIU C; CHUNG JY; STICKEL F; SEITZ HK; RUSSELL RM;
Indirizzi:
TUFTS UNIV,USDA,HUMAN NUTR RES CTR AGING,GASTROINTESTINAL NUTR LAB,JM,711 WASHINGTON ST BOSTON MA 02111 SALEM MED CTR,DEPT MED HEIDELBERG GERMANY
Titolo Testata:
Hepatology
fascicolo: 3, volume: 28, anno: 1998,
pagine: 744 - 750
SICI:
0270-9139(1998)28:3<744:CAIRRA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC ETHANOL-CONSUMPTION; FERRET LIVER; VITAMIN-A; METABOLISM; INHIBITION; OXIDATION; DIFFERENTIATION; DEHYDROGENASE; PREVENTION; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
X.D. Wang et al., "CHRONIC ALCOHOL INTAKE REDUCES RETINOIC ACID CONCENTRATION AND ENHANCES AP-1 (C-JUN AND C-FOS) EXPRESSION IN RAT-LIVER", Hepatology, 28(3), 1998, pp. 744-750

Abstract

Chronic ethanol intake may interfere with retinoid signal transduction by inhibiting retinoic acid synthesis and by enhancing activator protein-1 (AP-1) (c-Jun and c-Fos) expression, thereby contributing to malignant transformation. To determine the effect of ethanol on hepatic retinoid levels, retinoic acid receptors (RARs) and AP-1 (c-Jun and c-Fos) gene expression, chronic ethanol (36% of total calorie intake) pair-feeding was conducted on rats for a 1-month period. Retinoic acid, retinol, and retinyl ester concentrations in both liver and plasma were examined by using high-performance liquid chromatography (HPLC). Both retinoic acid receptor (alpha, beta, gamma) and AP-1 (c-Jun and c-Fos) expression in the rat liver were examined by using Western blot analysis. Treatment with high-dose ethanol led to a significant reductionof retinoic acid concentration in both the liver and the plasma (11- and 8.5-fold reduction, respectively), as compared with animals pair-fed an isocaloric control diet containing the same amount of vitamin A. Similar to the retinoic acid reductions, both retinol and retinyl palmitate levels in the livers of the alcohol-fed group decreased significantly, but in smaller fold reduction (6.5- and 2.6-fold reduction, respectively). Ethanol did not modulate the expression of RAR alpha, -beta, and -gamma genes in the liver. However, chronic alcohol feeding enhanced AP-1 (c-Jun and c-Fos) expression by 7- to 8-fold, as compared with the control group. These data suggest that functional downregulation of RARs by inhibiting biosynthesis of retinoic acid and up-regulation of AP-1 gene expression may be important mechanisms for causing malignant transformation by ethanol.

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Documento generato il 26/01/20 alle ore 17:13:59