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Titolo:
EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE MESSENGER-RNA IN BROWN-NORWAY RATS EXPOSED TO OZONE - EFFECT OF DEXAMETHASONE
Autore:
HADDAD EB; LIU SF; SALMON M; ROBICHAUD A; BARNES PJ; CHUNG KF;
Indirizzi:
NATL HEART & LUNG INST,DEPT THORAC MED,DOVEHOUSE ST LONDON SW3 6LY ENGLAND NATL HEART & LUNG INST,DEPT THORAC MED LONDON SW3 6LY ENGLAND
Titolo Testata:
European journal of pharmacology. Environmental toxicology and pharmacology section
fascicolo: 3, volume: 293, anno: 1995,
pagine: 287 - 290
SICI:
0926-6917(1995)293:3<287:EOINSM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; LIPOPOLYSACCHARIDE;
Keywords:
NITRIC OXIDE (NO); OZONE; NITRIC OXIDE (NO) SYNTHASE; MESSENGER-RNA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
E.B. Haddad et al., "EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE MESSENGER-RNA IN BROWN-NORWAY RATS EXPOSED TO OZONE - EFFECT OF DEXAMETHASONE", European journal of pharmacology. Environmental toxicology and pharmacology section, 293(3), 1995, pp. 287-290

Abstract

We studied the effects of ozone exposure and dexamethasone on inducible nitric oxide synthase (iNOS) gene expression in Brown Norway rats in vivo. Using a murine iNOS cDNA probe, we detected a 4.4 kb iNOS mRNAby Northern analysis in rat lung. The iNOS signal was weak in controllungs, but increased in lungs exposed to ozone (3 ppm, 6 h). Ozone-induced iNOS mRNA expression was time-dependent, with maximal expressionat 2 h, declining by 8 h and increasing again at 24 h postexposure. Dexamethasone significantly reduced the iNOS mRNA expression in the lungs of both controls and ozone-exposed rats. These results demonstrate that ozone inhalation induces iNOS expression in vivo, thus providing evidence at the molecular level for the possible involvement of nitricoxide generation in ozone-induced pulmonary inflammation or lung damage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:10:32