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Titolo: EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE MESSENGER-RNA IN BROWN-NORWAY RATS EXPOSED TO OZONE - EFFECT OF DEXAMETHASONE
Autore: HADDAD EB; LIU SF; SALMON M; ROBICHAUD A; BARNES PJ; CHUNG KF;
- Indirizzi:
- NATL HEART & LUNG INST,DEPT THORAC MED,DOVEHOUSE ST LONDON SW3 6LY ENGLAND NATL HEART & LUNG INST,DEPT THORAC MED LONDON SW3 6LY ENGLAND
- Titolo Testata:
- European journal of pharmacology. Environmental toxicology and pharmacology section
fascicolo: 3,
volume: 293,
anno: 1995,
pagine: 287 - 290
- SICI:
- 0926-6917(1995)293:3<287:EOINSM>2.0.ZU;2-J
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- MESSENGER-RNA; LIPOPOLYSACCHARIDE;
- Keywords:
- NITRIC OXIDE (NO); OZONE; NITRIC OXIDE (NO) SYNTHASE; MESSENGER-RNA;
- Tipo documento:
- Note
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 17
- Recensione:
- Indirizzi per estratti:
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- Citazione:
- E.B. Haddad et al., "EXPRESSION OF INDUCIBLE NITRIC-OXIDE SYNTHASE MESSENGER-RNA IN BROWN-NORWAY RATS EXPOSED TO OZONE - EFFECT OF DEXAMETHASONE", European journal of pharmacology. Environmental toxicology and pharmacology section, 293(3), 1995, pp. 287-290
Abstract
We studied the effects of ozone exposure and dexamethasone on inducible nitric oxide synthase (iNOS) gene expression in Brown Norway rats in vivo. Using a murine iNOS cDNA probe, we detected a 4.4 kb iNOS mRNAby Northern analysis in rat lung. The iNOS signal was weak in controllungs, but increased in lungs exposed to ozone (3 ppm, 6 h). Ozone-induced iNOS mRNA expression was time-dependent, with maximal expressionat 2 h, declining by 8 h and increasing again at 24 h postexposure. Dexamethasone significantly reduced the iNOS mRNA expression in the lungs of both controls and ozone-exposed rats. These results demonstrate that ozone inhalation induces iNOS expression in vivo, thus providing evidence at the molecular level for the possible involvement of nitricoxide generation in ozone-induced pulmonary inflammation or lung damage.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:10:32