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Titolo:
MITOCHONDRIAL SENSITIVITY TO AZT
Autore:
PEREIRA LF; OLIVEIRA MBM; CARNIERI EGS;
Indirizzi:
UFPR,DEPT BIOQUIM,CAIXA POSTAL 19046 BR-81531990 CURITIBA PARANA BRAZIL UFPR,DEPT BIOQUIM BR-81531990 CURITIBA PARANA BRAZIL PONTIF UNIV CATOLICA PARANA CURITIBA PARANA BRAZIL
Titolo Testata:
Cell biochemistry and function
fascicolo: 3, volume: 16, anno: 1998,
pagine: 173 - 181
SICI:
0263-6484(1998)16:3<173:MSTA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE MITOCHONDRIA; RAT-LIVER MITOCHONDRIA; HEART-MITOCHONDRIA; IN-VITRO; ZIDOVUDINE MYOPATHY; NADH DEHYDROGENASE; ANTIVIRAL DRUGS; 3'-AZIDO-3'-DEOXYTHYMIDINE; THERAPY; CARRIER;
Keywords:
AZT; MITOCHONDRIAL DISEASE; BIOENERGETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
L.F. Pereira et al., "MITOCHONDRIAL SENSITIVITY TO AZT", Cell biochemistry and function, 16(3), 1998, pp. 173-181

Abstract

The possibility of tissue-specific effects regarding mitochondrial sensitivity to AZT was evaluated in this study. When mitochondria isolated from liver, kidney, skeletal and cardiac muscle were oxidizing glutamate, a dose-dependent inhibition by AZT of state 3 respiration was observed; using succinate as substrate the inhibition occurred only in skeletal and cardiac muscle mitochondria. The same results were obtained with FCCP-uncoupled mitochondria. NADH oxidase of intact and disrupted mitochondria, isolated from all four tissues was strongly inhibited. Succinate oxidase activity was inhibited by AZT only in intact mitochondria from skeletal and cardiac muscles, suggesting the involvementof succinate transport systems. Similarly, inhibition by the drug of the hydrolytic activity of Hf-ATPase was observed only in mitochondriaof these tissues. These effects taken together, indicate a tissue/carrier-specific inhibition in vitro, although its precise mechanism requires further research. (C) 1998 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 15:05:29