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Titolo:
DIFFERENCES IN REGIONAL BRAIN METABOLIC RESPONSES BETWEEN SINGLE AND REPEATED DOSES OF METHYLPHENIDATE
Autore:
VOLKOW ND; WANG GJ; FOWLER JS; HITZEMANN R; GATLEY J; DING YS; WONG C; PAPPAS N;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED,BLDG 490 UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 1, volume: 83, anno: 1998,
pagine: 29 - 36
SICI:
0925-4927(1998)83:1<29:DIRBMR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; GLUCOSE-UTILIZATION; INTRAVENOUS DEXTROAMPHETAMINE; COCAINE; HUMANS; HYPERACTIVITY; AMPHETAMINE; RECEPTORS; ADULTS; RAT;
Keywords:
DRUG ADDICTION; BINGEING; COCAINE; FDG; PET; CRAVING; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Volkow et al., "DIFFERENCES IN REGIONAL BRAIN METABOLIC RESPONSES BETWEEN SINGLE AND REPEATED DOSES OF METHYLPHENIDATE", PSYCHIATRY RESEARCH-NEUROIMAGING, 83(1), 1998, pp. 29-36

Abstract

Studies investigating the acute effects of drugs of abuse on human brain metabolism have measured single doses whereas these drugs are mostly taken repeatedly. Here we compared the brain metabolic response to intravenous methylphenidate when given after a single dose to that when given after two sequential doses. Methylphenidate-induced changes inmetabolism differed; whereas single doses tended to decrease metabolism, repeated doses tended to increase it, and these differences were significant in frontal, parietal and occipital cortices and hippocampus. This indicates that methylphenidate's metabolic effects vary with acute previous exposure and highlights the importance of studying drugs after single and repeated administration. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:40:05