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Titolo:
MK-801, MEMANTINE AND AMANTADINE SHOW NEUROPROTECTIVE ACTIVITY IN THENUCLEUS BASALIS MAGNOCELLULARIS
Autore:
WENK GL; DANYSZ W; MOBLEY SL;
Indirizzi:
UNIV ARIZONA,DIV NEURAL SYST MEMORY & AGING,ARIZONA RES LABS,384 LIFESCI N TUCSON AZ 85724 MERZ & CO GMBH & CO,DEPT PHARMACOL D-60318 FRANKFURT GERMANY
Titolo Testata:
European journal of pharmacology. Environmental toxicology and pharmacology section
fascicolo: 3, volume: 293, anno: 1995,
pagine: 267 - 270
SICI:
0926-6917(1995)293:3<267:MMAASN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA-RECEPTOR; ANTAGONISTS; NEUROTOXICITY; MECHANISMS; DISEASE; CHANNEL; BLOCK; DRUGS;
Keywords:
NUCLEUS BASALIS MAGNOCELLULARIS; ACETYLCHOLINE; NEUROPROTECTION; MEMANTINE; (+)-MK-801; AMANTADINE; ATAXIA; STEREOTYPY; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
G.L. Wenk et al., "MK-801, MEMANTINE AND AMANTADINE SHOW NEUROPROTECTIVE ACTIVITY IN THENUCLEUS BASALIS MAGNOCELLULARIS", European journal of pharmacology. Environmental toxicology and pharmacology section, 293(3), 1995, pp. 267-270

Abstract

The activation of glutamate receptors by endogenous glutamate has been implicated in the processes that underlie cell loss associated with ischemia and trauma and in the development of some neurodegenerative diseases. The antagonism of NMDA-sensitive glutamate receptors may therefore have therapeutic applications. The present study compared the side effects and neuroprotective potency of 1-aminoadamantane hydrochloride (amantadine), 1-amino-3,5-dimethyladamantane hydrochloride (memantine), and -5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10 maleate ((+)-MK-801) against NMDA injected directly into the nucleus basalis magnocellularis of rats. Each drug significantly attenuated the loss of nucleus basalis magnocellularis cholinergic cells. The ED(50)s were respectively 0.077, 2.81 and 43.5 mg/kg for (+)-MK-801, memantine and amantadine, giving a relative potency ratio of 1:36:565. The ratio of the EDS, for the side effects observed, including ataxia, myorelaxation and stereotypy, and the ED(50) for neuroprotective ability, was highest for memantine and the lowest for (+)-MK-801. The results suggest that a potential neuroprotective action of NMDA receptor antagonists, memantine and amantadine in particular, can be seen at low doses lacking side effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 22:40:15