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Titolo:
LAT PALMITOYLATION - ITS ESSENTIAL ROLE IN MEMBRANE MICRODOMAIN TARGETING AND TYROSINE PHOSPHORYLATION DURING T-CELL ACTIVATION
Autore:
ZHANG WG; TRIBLE RP; SAMELSON LE;
Indirizzi:
NATIONAL INSTITUTE CHILD HEALTH & HUMAN DEV,CELL BIOL & METAB BRANCH,SECT LYMPHOCYTE SIGNALING BETHESDA MD 20892 NATIONAL INSTITUTE CHILD HEALTH & HUMAN DEV,CELL BIOL & METAB BRANCH,SECT LYMPHOCYTE SIGNALING BETHESDA MD 20892
Titolo Testata:
Immunity (Cambridge, Mass.)
fascicolo: 2, volume: 9, anno: 1998,
pagine: 239 - 246
SICI:
1074-7613(1998)9:2<239:LP-IER>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; ANTIGEN RECEPTOR; G-PROTEINS; KINASE; LOCALIZATION; DOMAINS; CAVEOLAE; MYRISTYLATION; PALMITYLATION; ACYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
W.G. Zhang et al., "LAT PALMITOYLATION - ITS ESSENTIAL ROLE IN MEMBRANE MICRODOMAIN TARGETING AND TYROSINE PHOSPHORYLATION DURING T-CELL ACTIVATION", Immunity (Cambridge, Mass.), 9(2), 1998, pp. 239-246

Abstract

The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds Grb2, PLC-gamma 1, and other signaling molecules. We demonstrate that human LAT is palmitoylated and that palmitoylated LAT predominantly localizes into glycolipid-enriched microdomains (GEMs). Although the LAT transmembrane domain is sufficient for membrane localization, palmitoylation at C26 and C29 is essential for efficient partitioning into GEMs. LAT palmitoylation is necessary for its tyrosine phosphorylation. After T cell activation, most tyrosine-phosphorylated LAT molecules and a fraction of PLC-gamma 1 and other signaling molecules are present in GEMs. LAT is central to T cell activation and is a novel linker molecule shownto require targeting to membrane microdomains for signaling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:34:59