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Titolo:
A MOLECULAR MAP OF T-CELL DEVELOPMENT
Autore:
SANTANGELO DB; LUCAS B; WATERBURY PG; COHEN B; BRABB T; GOVERMAN J; GERMAIN RN; JANEWAY CA;
Indirizzi:
YALE UNIV,HOWARD HUGHES MED INST,SCH MED,IMMUNOL SECT NEW HAVEN CT 06520 YALE UNIV,HOWARD HUGHES MED INST,SCH MED,IMMUNOL SECT NEW HAVEN CT 06520 NATIONAL INSTITUTE ALLERGY & INFECTIOUS DISEASES,IMMUNOL LAB,NIH BETHESDA MD 20892 UNIV WASHINGTON,SCH MED,DEPT MOL BIOTECHNOL SEATTLE WA 98195
Titolo Testata:
Immunity (Cambridge, Mass.)
fascicolo: 2, volume: 9, anno: 1998,
pagine: 179 - 186
SICI:
1074-7613(1998)9:2<179:AMMOTD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHAIN GENE REARRANGEMENT; POSITIVE SELECTION; MATURATION PATHWAY; INTERMEDIATE STEPS; THYMOCYTES; DIFFERENTIATION; RECOMBINATION; COMMITMENT; LINEAGES; THYMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.B. Santangelo et al., "A MOLECULAR MAP OF T-CELL DEVELOPMENT", Immunity (Cambridge, Mass.), 9(2), 1998, pp. 179-186

Abstract

Using a sensitive molecular marker for positive selection, the appearance of a particular functional TCR alpha chain sequence in cells frommice bearing a transgenic beta chain, we address several aspects of intrathymic T cell development. First, by examining specific TCR prior to and after maturation, we demonstrate how a restricted TCR repertoire is positively selected from a highly diverse immature TCR repertoire. Second, since this molecular marker is enriched in cells progressingtoward the CD4 lineage and depleted in cells progressing toward the CD8 lineage, a map of the developmental pathway of alpha beta thymocytes can be inferred. Third, the first cells that show clear signs of positive intrathymic selection are identified.

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Documento generato il 04/07/20 alle ore 14:18:08