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Titolo:
A CRITICAL WINDOW FOR COOPERATION AND COMPETITION AMONG DEVELOPING RETINOTECTAL SYNAPSES
Autore:
ZHANG LI; TAO HW; HOLT CE; HARRIS WA; POO MM;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093
Titolo Testata:
Nature
fascicolo: 6697, volume: 395, anno: 1998,
pagine: 37 - 44
SICI:
0028-0836(1998)395:6697<37:ACWFCA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; OCULAR DOMINANCE COLUMNS; VISUAL-CORTEX; NMDA RECEPTORS; MAP FORMATION; SEGREGATION; PROJECTION; CELLS; CONNECTIVITY; TRANSMISSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
L.I. Zhang et al., "A CRITICAL WINDOW FOR COOPERATION AND COMPETITION AMONG DEVELOPING RETINOTECTAL SYNAPSES", Nature, 395(6697), 1998, pp. 37-44

Abstract

In the developing frog visual system, topographic refinement of the retinotectal projection depends on electrical activity. In vivo whole-cell recording from developing Xenopus tectal neurons shows that convergent retinotectal synapses undergo activity-dependent cooperation and competition following correlated pre- and postsynaptic spiking within a narrow time window. Synaptic inputs activated repetitively within 20ms before spiking of the tectal neuron become potentiated, whereas subthreshold inputs activated within 20 ms after spiking become depressed. Thus both the initial synaptic strength and the temporal order of activation are critical for heterosynaptic interactions among convergent synaptic inputs during activity-dependent refinement of developing neural networks.

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Documento generato il 30/03/20 alle ore 19:55:17